TY - JOUR
T1 - Electrospun nanofibers for cancer diagnosis and therapy
AU - Chan, Zhou
AU - Chen, Zhaofeng
AU - Zhang, Aili
AU - Hu, Jiaming
AU - Wang, Xinmei
AU - Yang, Zhaogang
N1 - Publisher Copyright:
© 2016 The Royal Society of Chemistry.
PY - 2016/6
Y1 - 2016/6
N2 - The advent of nanotechnology has provided unprecedented opportunities for nanomedicine. Electrospun nanofibers have some astounding features such as high loading capacity, extremely large surface area and porosity, high encapsulation efficiency, ease of modification, combination of diverse therapies, low cost and great benefits. These remarkable structure-dependent properties have far reaching application potential in cancer diagnosis and therapy such as ultra-sensitive sensing systems for point-of-care cancer detection, targeted cancer cell capture, and functional and smart anticancer drug delivery systems. This review summarizes the principal mechanism of electrospun nanofibers and a variety of modified electrospun nanofibers, illustrates their application in biosensors for cancer detection, and enumerates their application in implantable drug delivery for cancer therapy.
AB - The advent of nanotechnology has provided unprecedented opportunities for nanomedicine. Electrospun nanofibers have some astounding features such as high loading capacity, extremely large surface area and porosity, high encapsulation efficiency, ease of modification, combination of diverse therapies, low cost and great benefits. These remarkable structure-dependent properties have far reaching application potential in cancer diagnosis and therapy such as ultra-sensitive sensing systems for point-of-care cancer detection, targeted cancer cell capture, and functional and smart anticancer drug delivery systems. This review summarizes the principal mechanism of electrospun nanofibers and a variety of modified electrospun nanofibers, illustrates their application in biosensors for cancer detection, and enumerates their application in implantable drug delivery for cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=84971267198&partnerID=8YFLogxK
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U2 - 10.1039/c6bm00070c
DO - 10.1039/c6bm00070c
M3 - Review article
C2 - 27048889
AN - SCOPUS:84971267198
SN - 2047-4830
VL - 4
SP - 922
EP - 932
JO - Biomaterials Science
JF - Biomaterials Science
IS - 6
ER -