Abstract

Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.

Original languageEnglish (US)
Pages (from-to)30-33
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Alzheimer's disease
  • T cells
  • dementia
  • inflammation
  • leukocytes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Elevated CNS inflammation in patients with preclinical Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this