Elevated Ferritin Is Associated with Relapse after Autologous Hematopoietic Stem Cell Transplantation for Lymphoma

Anuj Mahindra, Brian Bolwell, Ronald Sobecks, Lisa Rybicki, Brad Pohlman, Robert Dean, Steve Andresen, John Sweetenham, Matt Kalaycio, Edward Copelan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Elevated serum ferritin is associated with reduced survival following allogeneic transplantation and an increased risk of toxic and infectious complications after autologous hematopoietic stem cell transplantation (ASCT). We studied 315 patients who underwent ASCT for Hodgkin (HL) or non-Hodgkin lymphoma (NHL) at our institution in whom pretransplantation ferritin was available to determine its association with survival. On multivariate analysis, a pretransplantation ferritin >685 ng/mL was associated with significantly lower overall (OS; P = .002) and relapse-free survival (RFS; P = .021). Ferritin >685 ng/mL was associated with a higher incidence of relapse (P = .005) and relapse mortality (P < .001), but not of nonrelapse mortality (NRM; P = .23). Similar results were seen when pretransplantation ferritin was analyzed as a continuous variable and by quartiles. Our results indicate the need for studies designed to correlate an elevated ferritin with iron overload and to analyze the benefit of strategies to reduce the extent of iron overload.

Original languageEnglish (US)
Pages (from-to)1239-1244
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Ferritins
Lymphoma
Recurrence
Iron Overload
Survival
Pyridinolcarbamate
Mortality
Poisons
Homologous Transplantation
Hodgkin Disease
Non-Hodgkin's Lymphoma
Multivariate Analysis
Incidence
Serum

Keywords

  • Autologous hematopoietic transplantation
  • Iron overload
  • Pretransplantation ferritin

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Elevated Ferritin Is Associated with Relapse after Autologous Hematopoietic Stem Cell Transplantation for Lymphoma. / Mahindra, Anuj; Bolwell, Brian; Sobecks, Ronald; Rybicki, Lisa; Pohlman, Brad; Dean, Robert; Andresen, Steve; Sweetenham, John; Kalaycio, Matt; Copelan, Edward.

In: Biology of Blood and Marrow Transplantation, Vol. 14, No. 11, 01.11.2008, p. 1239-1244.

Research output: Contribution to journalArticle

Mahindra, A, Bolwell, B, Sobecks, R, Rybicki, L, Pohlman, B, Dean, R, Andresen, S, Sweetenham, J, Kalaycio, M & Copelan, E 2008, 'Elevated Ferritin Is Associated with Relapse after Autologous Hematopoietic Stem Cell Transplantation for Lymphoma', Biology of Blood and Marrow Transplantation, vol. 14, no. 11, pp. 1239-1244. https://doi.org/10.1016/j.bbmt.2008.08.009
Mahindra, Anuj ; Bolwell, Brian ; Sobecks, Ronald ; Rybicki, Lisa ; Pohlman, Brad ; Dean, Robert ; Andresen, Steve ; Sweetenham, John ; Kalaycio, Matt ; Copelan, Edward. / Elevated Ferritin Is Associated with Relapse after Autologous Hematopoietic Stem Cell Transplantation for Lymphoma. In: Biology of Blood and Marrow Transplantation. 2008 ; Vol. 14, No. 11. pp. 1239-1244.
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