Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population

Thomas P. Bersot, Gloria L Vega, Scott M Grundy, K. Erhan Palaoǧlu, Pamir Atagündüz, Sinan Özbayrakçi, Oryal Gökdemir, Robert W. Mahley

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Low levels of high density lipoprotein cholesterol (HDL-C) are associated with increased risk of coronary heart disease and, in the United States, are often associated with hypertriglyceridemia and obesity. In Turkey, low HDL-C levels are highly prevalent, 53% of men and 26% of women having HDL-C levels <35 mg/dl, in the absence of hypertriglyceridemia and obesity. In this study to investigate the cause of low HDL-C levels in Turks, various factors affecting HDL metabolism were assessed in normotriglyceridemic Turkish men and women living in Istanbul and in non- Turkish men and women living in San Francisco. Turkish men and women had significantly lower HDL-C levels than the San Francisco men and women, as well as markedly lower apolipoprotein A-I levels (25 and 39 mg/dl lower, respectively). In both Turkish and non-Turkish subjects, the mean body mass index was <27 kg/m2, the mean triglyceride level was < 120 mg/dl, and the mean total cholesterol was 170-180 mg/dl. The mean hepatic triglyceride lipase activity was 21% and 31% higher in Turkish men and women, respectively, than in non-Turkish men and women, and remained higher even after subjects with a body mass index >50th percentile for men and women in the United States were excluded from the analysis. As no dietary or behavioral factors have been identified in the Turkish population that account for increased hepatic triglyceride lipase activity, the elevation most likely has a genetic basis.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalJournal of Lipid Research
Volume40
Issue number3
StatePublished - Mar 1999

Fingerprint

HDL Lipoproteins
Lipase
HDL Cholesterol
Liver
Population
Hypertriglyceridemia
Turkey
LDL Cholesterol
Coronary Disease
Obesity

Keywords

  • Apolipoprotein A-I
  • Body mass index
  • Cholesteryl ester transfer protein
  • Lecithin:cholesterol acyltransferase
  • Lipoprotein lipase
  • Triglycerides

ASJC Scopus subject areas

  • Endocrinology

Cite this

Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population. / Bersot, Thomas P.; Vega, Gloria L; Grundy, Scott M; Palaoǧlu, K. Erhan; Atagündüz, Pamir; Özbayrakçi, Sinan; Gökdemir, Oryal; Mahley, Robert W.

In: Journal of Lipid Research, Vol. 40, No. 3, 03.1999, p. 432-438.

Research output: Contribution to journalArticle

Bersot, TP, Vega, GL, Grundy, SM, Palaoǧlu, KE, Atagündüz, P, Özbayrakçi, S, Gökdemir, O & Mahley, RW 1999, 'Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population', Journal of Lipid Research, vol. 40, no. 3, pp. 432-438.
Bersot, Thomas P. ; Vega, Gloria L ; Grundy, Scott M ; Palaoǧlu, K. Erhan ; Atagündüz, Pamir ; Özbayrakçi, Sinan ; Gökdemir, Oryal ; Mahley, Robert W. / Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population. In: Journal of Lipid Research. 1999 ; Vol. 40, No. 3. pp. 432-438.
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