Abstract
Background: The presence of silent cerebral infarction (SCI) increases the risk of transient ischaemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addition, MPV is a risk predictor for cardiovascular disease, stroke and overall vascular mortality. Aims: The purpose of the study was to assess the MPV levels in SCI patients. Methods: A cross-sectional study was conducted to evaluate the association between MPV and SCI in 2215 subjects (1385 men and 830 women). Results: The participants with SCI had higher MPV levels than those without SCI (10.4 ± 1.3fL vs. 9.2 ± 1.2fL; P < 0.001). Moreover, the subjects with a high MPV had a higher prevalence of SCI. Multivariate logistic regression analyses revealed that the odds ratios and 95% confidence intervals for SCI according to MPV quartiles were 1.000, 2.131 (1.319-3.444), 3.015 (1.896-4.794), 7.822 (4.874-12.554) respectively (P < 0.001). Conclusion: MPV is a novel index for SCI regardless of classical cardiovascular risk factors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 653-657 |
| Number of pages | 5 |
| Journal | Internal Medicine Journal |
| Volume | 44 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2014 |
Keywords
- Atherosclerosis
- Mean platelet volume
- Platelet activation
- Risk factor
- Silent cerebral infarction
ASJC Scopus subject areas
- Internal Medicine