Elevated mean platelet volume predicts poor prognosis in colorectal cancer

Na Li, Zhiwei Yu, Xin Zhang, Tiemin Liu, Yu Xiang Sun, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118-1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.

Original languageEnglish (US)
Article number10261
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Elevated mean platelet volume predicts poor prognosis in colorectal cancer'. Together they form a unique fingerprint.

  • Cite this

    Li, N., Yu, Z., Zhang, X., Liu, T., Sun, Y. X., Wang, R. T., & Yu, K. J. (2017). Elevated mean platelet volume predicts poor prognosis in colorectal cancer. Scientific Reports, 7(1), [10261]. https://doi.org/10.1038/s41598-017-11053-y