Elevated mean platelet volume predicts poor prognosis in colorectal cancer

Na Li; Zhiwei Yu; Xin Zhang; Tiemin Liu; Yu Xiang Sun; Rui Tao Wang; Kai Jiang Yu

doi:10.1038/s41598-017-11053-y

Elevated mean platelet volume predicts poor prognosis in colorectal cancer

Na Li, Zhiwei Yu, Xin Zhang, Tiemin Liu, Yu Xiang Sun, Rui Tao Wang, Kai Jiang Yu

Internal Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118-1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.

Original language	English (US)
Article number	10261
Journal	Scientific reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-11053-y
State	Published - Dec 1 2017

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@article{7e003ceb02b14d729e7fe87a0b66d874,

title = "Elevated mean platelet volume predicts poor prognosis in colorectal cancer",

abstract = "Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118-1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.",

author = "Na Li and Zhiwei Yu and Xin Zhang and Tiemin Liu and Sun, {Yu Xiang} and Wang, {Rui Tao} and Yu, {Kai Jiang}",

note = "Funding Information: This work was supported by Science Foundation of Heilongjiang Academy of Medical Science (Grant No. 201714) and Postdoctoral Scientific Research Development Fund (Grant No. LBH-Q16175). Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

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doi = "10.1038/s41598-017-11053-y",

language = "English (US)",

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journal = "Scientific reports",

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T1 - Elevated mean platelet volume predicts poor prognosis in colorectal cancer

AU - Li, Na

AU - Yu, Zhiwei

AU - Zhang, Xin

AU - Liu, Tiemin

AU - Sun, Yu Xiang

AU - Wang, Rui Tao

AU - Yu, Kai Jiang

N1 - Funding Information: This work was supported by Science Foundation of Heilongjiang Academy of Medical Science (Grant No. 201714) and Postdoctoral Scientific Research Development Fund (Grant No. LBH-Q16175). Publisher Copyright: © 2017 The Author(s).

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118-1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.

AB - Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118-1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.

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Elevated mean platelet volume predicts poor prognosis in colorectal cancer

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