Elevated mutation rates in the germline of Polκ mutant male mice

Karen L A Burr, Susana Velasco-Miguel, Venkata S. Duvvuri, Lisa D. McDaniel, Errol C. Friedberg, Yuri E. Dubrova

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polκ-/-) deficient mice. The spontaneous mutation rate in homozygous Polκ-/- males was significantly higher than in isogenic wild-type mice (Polκ+/+), but the ESTR mutation spectrum in Polκ-/- animals did not differ from that in Polκ+/+ males. We suggest that compromised translesion synthesis in Polκ-/- mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.

Original languageEnglish (US)
Pages (from-to)860-862
Number of pages3
JournalDNA repair
Volume5
Issue number7
DOIs
StatePublished - Jul 13 2006

Keywords

  • DNA polymerase kappa
  • Expanded simple tandem repeat loci
  • Germline mutation
  • Mice

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Burr, K. L. A., Velasco-Miguel, S., Duvvuri, V. S., McDaniel, L. D., Friedberg, E. C., & Dubrova, Y. E. (2006). Elevated mutation rates in the germline of Polκ mutant male mice. DNA repair, 5(7), 860-862. https://doi.org/10.1016/j.dnarep.2006.04.003