Elevated mutation rates in the germline of Polκ mutant male mice

Karen L A Burr, Susana Velasco-Miguel, Venkata S. Duvvuri, Lisa D. McDaniel, Errol C. Friedberg, Yuri E. Dubrova

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polκ-/-) deficient mice. The spontaneous mutation rate in homozygous Polκ-/- males was significantly higher than in isogenic wild-type mice (Polκ+/+), but the ESTR mutation spectrum in Polκ-/- animals did not differ from that in Polκ+/+ males. We suggest that compromised translesion synthesis in Polκ-/- mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.

Original languageEnglish (US)
Pages (from-to)860-862
Number of pages3
JournalDNA Repair
Volume5
Issue number7
DOIs
StatePublished - Jul 13 2006

Fingerprint

Tandem Repeat Sequences
Mutation Rate
DNA-Directed DNA Polymerase
Animals
Mutation

Keywords

  • DNA polymerase kappa
  • Expanded simple tandem repeat loci
  • Germline mutation
  • Mice

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Burr, K. L. A., Velasco-Miguel, S., Duvvuri, V. S., McDaniel, L. D., Friedberg, E. C., & Dubrova, Y. E. (2006). Elevated mutation rates in the germline of Polκ mutant male mice. DNA Repair, 5(7), 860-862. https://doi.org/10.1016/j.dnarep.2006.04.003

Elevated mutation rates in the germline of Polκ mutant male mice. / Burr, Karen L A; Velasco-Miguel, Susana; Duvvuri, Venkata S.; McDaniel, Lisa D.; Friedberg, Errol C.; Dubrova, Yuri E.

In: DNA Repair, Vol. 5, No. 7, 13.07.2006, p. 860-862.

Research output: Contribution to journalArticle

Burr, KLA, Velasco-Miguel, S, Duvvuri, VS, McDaniel, LD, Friedberg, EC & Dubrova, YE 2006, 'Elevated mutation rates in the germline of Polκ mutant male mice', DNA Repair, vol. 5, no. 7, pp. 860-862. https://doi.org/10.1016/j.dnarep.2006.04.003
Burr KLA, Velasco-Miguel S, Duvvuri VS, McDaniel LD, Friedberg EC, Dubrova YE. Elevated mutation rates in the germline of Polκ mutant male mice. DNA Repair. 2006 Jul 13;5(7):860-862. https://doi.org/10.1016/j.dnarep.2006.04.003
Burr, Karen L A ; Velasco-Miguel, Susana ; Duvvuri, Venkata S. ; McDaniel, Lisa D. ; Friedberg, Errol C. ; Dubrova, Yuri E. / Elevated mutation rates in the germline of Polκ mutant male mice. In: DNA Repair. 2006 ; Vol. 5, No. 7. pp. 860-862.
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