Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults

Danielle E. Eagan, Mitzi M. Gonzales, Takashi Tarumi, Hirofumi Tanaka, Sandra Stautberg, Andreana P. Haley

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and 1H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F (4,31) = 4.74, P = 0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F (5,30) = 4.356, CRP β = 0.322, P = 0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.

Original languageEnglish (US)
Article number120540
JournalCardiovascular Psychiatry and Neurology
DOIs
StatePublished - Mar 21 2012

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Inositol
C-Reactive Protein
Blood Proteins
Creatine
Brain
Risk Adjustment
Sex Education
Choline
Cognition
Dementia
Protons
Glutamic Acid
Magnetic Resonance Spectroscopy
Biomarkers
Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Psychiatry and Mental health
  • Clinical Neurology
  • Neurology

Cite this

Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults. / Eagan, Danielle E.; Gonzales, Mitzi M.; Tarumi, Takashi; Tanaka, Hirofumi; Stautberg, Sandra; Haley, Andreana P.

In: Cardiovascular Psychiatry and Neurology, 21.03.2012.

Research output: Contribution to journalArticle

Eagan, Danielle E. ; Gonzales, Mitzi M. ; Tarumi, Takashi ; Tanaka, Hirofumi ; Stautberg, Sandra ; Haley, Andreana P. / Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults. In: Cardiovascular Psychiatry and Neurology. 2012.
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