Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis

Tianfu Wu, Chun Xie, Hong W. Wang, Xin J. Zhou, Noa Schwartz, Sergio Calixto, Meggan Mackay, Cynthia Aranow, Chaim Putterman, Chandra Mohan

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

In an effort to identify potential biomarkers in lupus nephritis, urine from mice with spontaneous lupus nephritis was screened for the presence of VCAM-1, P-selectin, TNFR-1, and CXCL16, four molecules that had previously been shown to be elevated in experimental immune nephritis, particularly at the peak of disease. Interestingly, all four molecules were elevated ∼2- to 4-fold in the urine of several strains of mice with spontaneous lupus nephritis, including the MRL/lpr, NZM2410, and B6.Sle1.lpr strains, correlating well with proteinuria. VCAM-1, P-selectin, TNFR-1, and CXCL16 were enriched in the urine compared with the serum particularly in active disease, and were shown to be expressed within the diseased kidneys. Finally, all four molecules were also elevated in the urine of patients with lupus nephritis, correlating well with urine protein levels and systemic lupus erythematosus disease activity index scores. In particular, urinary VCAM-1 and CXCL16 showed superior specificity and sensitivity in distinguishing subjects with active renal disease from the other systemic lupus erythematosus patients. These studies uncover VCAM-1, P-selectin, TNFR-1, and CXCL16 as a quartet of molecules that may have potential diagnostic significance in lupus nephritis. Longitudinal studies are warranted to establish the clinical use of these potential biomarkers.

Original languageEnglish (US)
Pages (from-to)7166-7175
Number of pages10
JournalJournal of Immunology
Volume179
Issue number10
StatePublished - Nov 15 2007

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CXC Chemokines
Lupus Nephritis
P-Selectin
Vascular Cell Adhesion Molecule-1
Tumor Necrosis Factor Receptors
Urine
Ligands
Systemic Lupus Erythematosus
Biomarkers
Nephritis
Kidney Diseases
Proteinuria
Longitudinal Studies
Kidney
Sensitivity and Specificity
Serum
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Wu, T., Xie, C., Wang, H. W., Zhou, X. J., Schwartz, N., Calixto, S., ... Mohan, C. (2007). Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. Journal of Immunology, 179(10), 7166-7175.

Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. / Wu, Tianfu; Xie, Chun; Wang, Hong W.; Zhou, Xin J.; Schwartz, Noa; Calixto, Sergio; Mackay, Meggan; Aranow, Cynthia; Putterman, Chaim; Mohan, Chandra.

In: Journal of Immunology, Vol. 179, No. 10, 15.11.2007, p. 7166-7175.

Research output: Contribution to journalArticle

Wu, T, Xie, C, Wang, HW, Zhou, XJ, Schwartz, N, Calixto, S, Mackay, M, Aranow, C, Putterman, C & Mohan, C 2007, 'Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis', Journal of Immunology, vol. 179, no. 10, pp. 7166-7175.
Wu, Tianfu ; Xie, Chun ; Wang, Hong W. ; Zhou, Xin J. ; Schwartz, Noa ; Calixto, Sergio ; Mackay, Meggan ; Aranow, Cynthia ; Putterman, Chaim ; Mohan, Chandra. / Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. In: Journal of Immunology. 2007 ; Vol. 179, No. 10. pp. 7166-7175.
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abstract = "In an effort to identify potential biomarkers in lupus nephritis, urine from mice with spontaneous lupus nephritis was screened for the presence of VCAM-1, P-selectin, TNFR-1, and CXCL16, four molecules that had previously been shown to be elevated in experimental immune nephritis, particularly at the peak of disease. Interestingly, all four molecules were elevated ∼2- to 4-fold in the urine of several strains of mice with spontaneous lupus nephritis, including the MRL/lpr, NZM2410, and B6.Sle1.lpr strains, correlating well with proteinuria. VCAM-1, P-selectin, TNFR-1, and CXCL16 were enriched in the urine compared with the serum particularly in active disease, and were shown to be expressed within the diseased kidneys. Finally, all four molecules were also elevated in the urine of patients with lupus nephritis, correlating well with urine protein levels and systemic lupus erythematosus disease activity index scores. In particular, urinary VCAM-1 and CXCL16 showed superior specificity and sensitivity in distinguishing subjects with active renal disease from the other systemic lupus erythematosus patients. These studies uncover VCAM-1, P-selectin, TNFR-1, and CXCL16 as a quartet of molecules that may have potential diagnostic significance in lupus nephritis. Longitudinal studies are warranted to establish the clinical use of these potential biomarkers.",
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