Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy

Rachel Katz-Brull, Robert E. Lenkinski, Renaud A. Du Pasquier, Igor J. Koralnik

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.

Original languageEnglish (US)
Pages (from-to)897-900
Number of pages4
JournalNeurology
Volume63
Issue number5
DOIs
StatePublished - Sep 14 2004

ASJC Scopus subject areas

  • Clinical Neurology

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