Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy

Rachel Katz-Brull, Robert E. Lenkinski, Renaud A. Du Pasquier, Igor J. Koralnik

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.

Original languageEnglish (US)
Pages (from-to)897-900
Number of pages4
JournalNeurology
Volume63
Issue number5
StatePublished - Sep 14 2004

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Progressive Multifocal Leukoencephalopathy
Inositol
Survivors
JC Virus
Creatine
Cytotoxic T-Lymphocytes
Neuroglia
Disease Progression
Magnetic Resonance Spectroscopy
Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Katz-Brull, R., Lenkinski, R. E., Du Pasquier, R. A., & Koralnik, I. J. (2004). Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology, 63(5), 897-900.

Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. / Katz-Brull, Rachel; Lenkinski, Robert E.; Du Pasquier, Renaud A.; Koralnik, Igor J.

In: Neurology, Vol. 63, No. 5, 14.09.2004, p. 897-900.

Research output: Contribution to journalArticle

Katz-Brull, R, Lenkinski, RE, Du Pasquier, RA & Koralnik, IJ 2004, 'Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy', Neurology, vol. 63, no. 5, pp. 897-900.
Katz-Brull R, Lenkinski RE, Du Pasquier RA, Koralnik IJ. Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. Neurology. 2004 Sep 14;63(5):897-900.
Katz-Brull, Rachel ; Lenkinski, Robert E. ; Du Pasquier, Renaud A. ; Koralnik, Igor J. / Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy. In: Neurology. 2004 ; Vol. 63, No. 5. pp. 897-900.
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