TY - JOUR
T1 - Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy
AU - Katz-Brull, Rachel
AU - Lenkinski, Robert E.
AU - Du Pasquier, Renaud A.
AU - Koralnik, Igor J.
PY - 2004/9/14
Y1 - 2004/9/14
N2 - MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
AB - MRI, 1H-MR spectroscopy, immunologic, and virologic studies were performed in search of prognostic factors of disease evolution in patients with progressive multifocal leukoencephalopathy (PML). Acute lesions of PML survivors showed twofold higher standard score of the ratio of myoinositol (a glial marker) to creatine compared with lesions in patients whose disease progressed. Concomitantly, JC virus-specific cytotoxic T lymphocytes were only detected in the blood of PML survivors. These results suggest that inflammation limits disease progression.
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U2 - 10.1212/01.WNL.0000137420.58346.9F
DO - 10.1212/01.WNL.0000137420.58346.9F
M3 - Article
C2 - 15365144
AN - SCOPUS:4644264062
SN - 0028-3878
VL - 63
SP - 897
EP - 900
JO - Neurology
JF - Neurology
IS - 5
ER -