TY - JOUR
T1 - Elevation of plasma prolactin concentrations by intravenous SCH 23390 and SKF 38393 in conscious rats
AU - Kenji, Tanimoto
AU - Tamminga, Carol A.
AU - Chase, Thomas N.
PY - 1987/12/1
Y1 - 1987/12/1
N2 - The effect of the selective dopamine-1 (D-1) antagonist, SCH 23390 and the selective D-1 agonist, SKF 38393 on plasma prolactin levels was investigated in conscious, freely moving male rats. Plasma prolactin was markedly increased by the intravenous injection of either SCH 23390 or SKF 38393 in a dose-related fashion. The maximal prolactin response was observed 15 min after drug injection. The d-isomer of SKF 38393 was significantly more potent than the l-isomer. In urethane-anesthetized rats, the two drugs produced similar effects on prolactin as those in the conscious animal preparation. Both SCH 23390 and SKF 38393 potentiated the sulpiride-induced prolactin as those in the These observations suggest that pharmacologic stimulation, or blockade of D-1 receptors in the living animal, can mimic the action of a D2 antagonist at the anterior pituitary lactotroph. We have speculated on the possible mechanisms in pituitary and higher in the central nervous system which might be responsible for the prolactin changes caused by either SCH 23390 of SKF 38393.
AB - The effect of the selective dopamine-1 (D-1) antagonist, SCH 23390 and the selective D-1 agonist, SKF 38393 on plasma prolactin levels was investigated in conscious, freely moving male rats. Plasma prolactin was markedly increased by the intravenous injection of either SCH 23390 or SKF 38393 in a dose-related fashion. The maximal prolactin response was observed 15 min after drug injection. The d-isomer of SKF 38393 was significantly more potent than the l-isomer. In urethane-anesthetized rats, the two drugs produced similar effects on prolactin as those in the conscious animal preparation. Both SCH 23390 and SKF 38393 potentiated the sulpiride-induced prolactin as those in the These observations suggest that pharmacologic stimulation, or blockade of D-1 receptors in the living animal, can mimic the action of a D2 antagonist at the anterior pituitary lactotroph. We have speculated on the possible mechanisms in pituitary and higher in the central nervous system which might be responsible for the prolactin changes caused by either SCH 23390 of SKF 38393.
KW - (Rat)
KW - D-1 dopamine receptors
KW - D-2 dopamine receptors
KW - Prolactin (plasma)
KW - SCH 23390
KW - SKF 38393
UR - http://www.scopus.com/inward/record.url?scp=0023515132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023515132&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(87)90513-9
DO - 10.1016/0014-2999(87)90513-9
M3 - Article
C2 - 3325296
AN - SCOPUS:0023515132
SN - 0014-2999
VL - 144
SP - 147
EP - 151
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -