TY - JOUR
T1 - Elimination of central sleep apnea by cardiac valve replacement
T2 - A continuous follow-up study in patients with rheumatic valvular heart disease
AU - Ding, Ning
AU - Ni, Bu Qing
AU - Zhang, Xi Long
AU - Zha, Wang Jian
AU - Hutchinson, Sean Z.
AU - Lin, Wei
AU - Huang, Mao
AU - Zhang, Shi Jiang
AU - Wang, Hong
N1 - Funding Information:
This study was supported by the Priority Academic Program of Jiangsu Higher Education Institutions (Grants JX10231801 ) and Jiangsu Provincial Department of Education (Grants CXLX12_0557 ).
PY - 2014/8
Y1 - 2014/8
N2 - Background: Recent studies have suggested that cardiac surgery may affect sleep-disordered breathing (SDB) in chronic heart failure patients. However, the dynamic changes in sleep apnea and heart function after cardiac surgery and the mechanisms responsible for these changes remain unknown. Methods: Patients with rheumatic valvular heart disease (RVHD) and SDB were enrolled and followed up at three, six and 12. months after cardiac valve replacement (CVR). Baseline and follow-up clinical data consisting of NYHA classification, 6. min walk distance (6-MWD), medications, echocardiography, electrocardiography, chest X-ray, arterial blood gas, lung-to-finger circulation time (LFCT), and sleep data were collected and evaluated. Results: Twenty-four central sleep apnea (CSA) patients and 15 obstructive sleep apnea (OSA) patients completed three follow-up assessments. Comparison of the baseline parameters between OSA patients and CSA patients showed that CSA patients had a worse baseline cardiac function assessed by higher NYHA class, shorter 6-MWD, larger left atrial diameter, longer LFCT, and enhanced chemosensitivity (higher pH and lower arterial carbon dioxide tension (PaCO2)). A continuous significant elevation in 6-MWD and left ventricular ejection fraction and decrease in NYHA class, plasma BNP, and left atrial diameter were found in both CSA and OSA patients. When comparing CSA and OSA patients, the CSA indices were remarkably reduced at month 3 post CVR and sustained throughout the trial, whereas there were no significant decreases in OSA index and hypopnea index. pH values and LFCT were markedly decreased and PaCO2 markedly increased in patients with CSA at the end of the third months following CVR. These changes were sustained until the end of the trial. Conclusions: CSA patients with RVHD had a worse baseline cardiac function, enhanced chemosensitivity and disordered hemodynamic as compared with OSA patients with RVHD. CSA were eliminated after CVR; however, there were no changes in OSA. The elimination of CSA, post CVR, is associated with the combined efficacies of improvement of cardiac function, normalized chemosensitivity, and stabilized hemodynamic.
AB - Background: Recent studies have suggested that cardiac surgery may affect sleep-disordered breathing (SDB) in chronic heart failure patients. However, the dynamic changes in sleep apnea and heart function after cardiac surgery and the mechanisms responsible for these changes remain unknown. Methods: Patients with rheumatic valvular heart disease (RVHD) and SDB were enrolled and followed up at three, six and 12. months after cardiac valve replacement (CVR). Baseline and follow-up clinical data consisting of NYHA classification, 6. min walk distance (6-MWD), medications, echocardiography, electrocardiography, chest X-ray, arterial blood gas, lung-to-finger circulation time (LFCT), and sleep data were collected and evaluated. Results: Twenty-four central sleep apnea (CSA) patients and 15 obstructive sleep apnea (OSA) patients completed three follow-up assessments. Comparison of the baseline parameters between OSA patients and CSA patients showed that CSA patients had a worse baseline cardiac function assessed by higher NYHA class, shorter 6-MWD, larger left atrial diameter, longer LFCT, and enhanced chemosensitivity (higher pH and lower arterial carbon dioxide tension (PaCO2)). A continuous significant elevation in 6-MWD and left ventricular ejection fraction and decrease in NYHA class, plasma BNP, and left atrial diameter were found in both CSA and OSA patients. When comparing CSA and OSA patients, the CSA indices were remarkably reduced at month 3 post CVR and sustained throughout the trial, whereas there were no significant decreases in OSA index and hypopnea index. pH values and LFCT were markedly decreased and PaCO2 markedly increased in patients with CSA at the end of the third months following CVR. These changes were sustained until the end of the trial. Conclusions: CSA patients with RVHD had a worse baseline cardiac function, enhanced chemosensitivity and disordered hemodynamic as compared with OSA patients with RVHD. CSA were eliminated after CVR; however, there were no changes in OSA. The elimination of CSA, post CVR, is associated with the combined efficacies of improvement of cardiac function, normalized chemosensitivity, and stabilized hemodynamic.
KW - Cardiac function
KW - Cardiac valve replacement
KW - Central sleep apnea
KW - Obstructive sleep apnea
KW - Rheumatic valvular heart disease
KW - Sleep-disordered breathing
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U2 - 10.1016/j.sleep.2014.02.007
DO - 10.1016/j.sleep.2014.02.007
M3 - Article
C2 - 24938583
AN - SCOPUS:84905010808
SN - 1389-9457
VL - 15
SP - 880
EP - 886
JO - Sleep Medicine
JF - Sleep Medicine
IS - 8
ER -