Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

Arthur E. Frankel; Daniel K. Haapala; Richard L. Neubauer; Peter J. Fischinger

doi:10.1126/science.1257745

Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

Arthur E. Frankel, Daniel K. Haapala, Richard L. Neubauer, Peter J. Fischinger

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revenant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line.

Original language	English (US)
Pages (from-to)	1264-1266
Number of pages	3
Journal	Science
Volume	191
Issue number	4233
DOIs	https://doi.org/10.1126/science.1257745
State	Published - 1976

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title = "Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells",

abstract = "Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revenant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line.",

author = "Frankel, {Arthur E.} and Haapala, {Daniel K.} and Neubauer, {Richard L.} and Fischinger, {Peter J.}",

year = "1976",

doi = "10.1126/science.1257745",

language = "English (US)",

volume = "191",

pages = "1264--1266",

journal = "Science",

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T1 - Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

AU - Frankel, Arthur E.

AU - Haapala, Daniel K.

AU - Neubauer, Richard L.

AU - Fischinger, Peter J.

PY - 1976

Y1 - 1976

N2 - Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revenant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line.

AB - Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revenant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line.

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Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells

Abstract

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