ELISA HIV testing and viral culture in the screening of corneal tissue for transplant from medical examiner cases

E. Heck, C. Petty, A. Palestine, M. Luckenbach, S. Z. Salahuddin, R. Nussenblatt, W. Harris, C. Baxter, James P McCulley

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The spread of AIDS and its association with a retrovirus, commonly called T-lymphotropic virus type III (HIV) has produced great concern among those involved in transplantation about the possibility for transmission of this disease through tissue and organ transplant. Isolation of the virus from conjunctiva and tears further heightened this concern for corneal transplants. This review of medical examiner (ME) cases, a population in which high numbers of transplant corneas are retrieved, has revealed positive serologic tests for HIV in serum from 5 cases in 205 screens. These represent potential donors based on other standard medical criteria available at the time of collection. This tissue was also submitted for viral culture, and virus was recovered from the corneal tissue in McCarey-Kaufman (MK) media. These findings and case reviews are discussed.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalCornea
Volume8
Issue number2
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Ophthalmology

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    Heck, E., Petty, C., Palestine, A., Luckenbach, M., Salahuddin, S. Z., Nussenblatt, R., Harris, W., Baxter, C., & McCulley, J. P. (1989). ELISA HIV testing and viral culture in the screening of corneal tissue for transplant from medical examiner cases. Cornea, 8(2), 77-80. https://doi.org/10.1097/00003226-198906000-00001