Embolization therapy for benign prostatic hyperplasia: Influence of embolization particle size on gland perfusion

Olga Rachel Brook, Salomao Faintuch, Alexander Brook, S. Nahum Goldberg, Neil M. Rofsky, Robert E. Lenkinski

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Purpose To assess the influence of embolic size on the therapy response of prostatic arterial embolization (PAE) based on perfusional changes seen on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). Materials and Methods Twelve beagles underwent PAE, four dogs with each particle size: A: 100-300 μm; B: 300-500 μm; and C: 500-700 μm. Prior to and 1 month after the embolization all dogs underwent prostate DCE MRI. Results After embolization, time to maximal perfusion intensity for prostate parenchyma increased in B (188 vs. 135 sec, P = 0.023) and C (200 vs. 120 sec, P = 0.001), while it did not change for A (139 vs. 124 sec, P = 0.39). The maximal relative intensity increased after embolization in C (3.84 vs. 2.38, P < 0.001), while it did not change for A (2.50 vs. 2.44, P = 0.36) and B (3.23 vs. 2.9, P = 0.21). The extent of visualized intraprostatic urethral wall increased after embolization in B compared with A and C, 239.5 ± 138.1% vs. 56.1 ± 34.3, P = 0.04. Enhancement changes correlated with prostate volume changes: prostate volumes in A decreased less as compared with B and C (77 ± 34% vs. 56 ± 14%), P = 0.02. Conclusion The enhancement and morphological data are useful to monitor response to therapy after embolization. Embolization with 300-500 and 500-700 μm particle may provide better results than with 100-300 μm particles in a canine model. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)380-387
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number2
DOIs
StatePublished - Aug 1 2013

Keywords

  • benign prostatic hyperplasia
  • canine prostate
  • dynamic contrast enhanced MRI
  • prostatic artery embolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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