Embryo culture: Cleavage versus blastocyst stage

Research output: Chapter in Book/Report/Conference proceedingChapter


Since the first successful human in vitro fertilization (IVF) pregnancy nearly 40 years ago, numerous approaches have been taken in attempts to improve IVF outcomes. A more robust understanding of embryologic development has driven innovation in not only the culture technologies but also the timing of embryo transfer. In this chapter, we will review embryo culture systems and the effectiveness of cleavage vs blastocyst stage transfer, embryo followed by the discussion of the optimal embryo culture and transfer strategy in diminished ovarian reserve (DOR) patients.

Original languageEnglish (US)
Title of host publicationDiminished Ovarian Reserve and Assisted Reproductive Technologies
Subtitle of host publicationCurrent Research and Clinical Management
PublisherSpringer International Publishing
Number of pages11
ISBN (Electronic)9783030232351
ISBN (Print)9783030232344
StatePublished - Jan 1 2019


  • Blastocyst state
  • Cleavage stage
  • Diminished ovarian reserve
  • Embryo quality
  • In vitro fertilization
  • Poor responder

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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