Emergency lung biopsy in immunocompromised pediatric patients

R. P. Foglia, J. Shilyansky, E. W. Fonkalsrud

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Twenty-six lung biopsies were performed on immunocompromised children with interstitial pneumonia over a 4-year period. More than 50% of the patients had either bone marrow transplants or immunodeficiency syndromes. Biopsy diagnosis included viral, nonspecific interstitial pneumonitis, Pneumocystis carinii, and bacterial etiologies. Findings caused a change in treatment in 15 (58%) patients, and nine of these 15 (60%) survived. Survivors included five chidren with viral infections treated with antiviral agents. Only one of nine patients requiring preoperative intubation survived, while 11 of 17 (65%) not intubed before operation survived. Overall survival ws 46% and included 5 of 5 patients with leukemia, 2 of 3 patients with liver transplants, 2 of 6 patients with immunodeficiency syndromes, and 1 of 8 patients with bone marrow transplants. This report shows that (1) an infectious etiology was found in 65% of the cases; (2) there was a high incidence of viral pneumonitis; (3) biopsy indicated a change in treatment for the majority of the patients; (4) the change in treatment was associated with survival in 60%; (5) viral infections may be effectively treated; (6) the timely use of lung biopsy is an important adjunct in the diagnostic and therapeutic regimen for immuno-compromised children with interstitial pneumonia.

Original languageEnglish (US)
Pages (from-to)90-92
Number of pages3
JournalAnnals of Surgery
Volume210
Issue number1
StatePublished - 1989

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Immunocompromised Host
Emergencies
Pediatrics
Biopsy
Lung
Interstitial Lung Diseases
Virus Diseases
Transplants
Bone Marrow
Pneumocystis carinii
Survival
Therapeutics
Intubation
Antiviral Agents
Survivors
Pneumonia
Leukemia
Liver
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Foglia, R. P., Shilyansky, J., & Fonkalsrud, E. W. (1989). Emergency lung biopsy in immunocompromised pediatric patients. Annals of Surgery, 210(1), 90-92.

Emergency lung biopsy in immunocompromised pediatric patients. / Foglia, R. P.; Shilyansky, J.; Fonkalsrud, E. W.

In: Annals of Surgery, Vol. 210, No. 1, 1989, p. 90-92.

Research output: Contribution to journalArticle

Foglia, RP, Shilyansky, J & Fonkalsrud, EW 1989, 'Emergency lung biopsy in immunocompromised pediatric patients', Annals of Surgery, vol. 210, no. 1, pp. 90-92.
Foglia RP, Shilyansky J, Fonkalsrud EW. Emergency lung biopsy in immunocompromised pediatric patients. Annals of Surgery. 1989;210(1):90-92.
Foglia, R. P. ; Shilyansky, J. ; Fonkalsrud, E. W. / Emergency lung biopsy in immunocompromised pediatric patients. In: Annals of Surgery. 1989 ; Vol. 210, No. 1. pp. 90-92.
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