Emergency reversal of anticoagulation and antiplatelet therapies in neurosurgical patients: A review

Joseph E. Beshay, Howard Morgan, Christopher Madden, Wengui Yu, Ravindra Sarode

Research output: Contribution to journalReview article

45 Scopus citations


Intracranial hemorrhage (ICH) is a common problem encountered by neurosurgeons. Patient outcomes are influenced by hematoma size, growth, location, and the timing of evacuation, when indicated. Patients may have abnormal coagulation due to pharmacological anticoagulation or coagulopathy due to underlying systemic disease or blood transfusions. Strategies to reestablish the integrity of the clotting cascade and platelet function assume a familiarity with these processes. As patients are increasingly treated with anticoagulants and antiplatelet agents, it is essential that the physicians who care for patients with ICH understand these pathways and recognize how they can be manipulated to restore hemostasis.

Original languageEnglish (US)
Pages (from-to)307-318
Number of pages12
JournalJournal of neurosurgery
Issue number2
StatePublished - Feb 1 2010



  • Anticoagulant
  • Antiplatelet agent
  • Coagulopathy
  • Intracranial hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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