TY - JOUR
T1 - Emerging concepts in CD8+ T regulatory cells
AU - Niederkorn, Jerry Y.
N1 - Funding Information:
The work is supported by NIH grants EY007641, EY005631, and EY016664 and an unrestricted grant from Research to Prevent Blindness.
PY - 2008/6
Y1 - 2008/6
N2 - CD8+ T regulatory cells (T regs) are elicited by unique antigen presenting cells during viral infections, by manipulation of co-stimulatory molecules, or in the development of tumors. CD8+ T regs display antigen-specificity, which is most exquisitely manifested by the HLA-E-restricted cytolytic CD8+ T regs in MS. There is evidence that some CD8+ T regs also express organ specificity. In many cases, IFN-γ is required for either the induction or expression of CD8+ T regs. CD8+ T regs can produce suppression directly by killing immune cells or indirectly by co-opting other cells to elaborate end-stage suppressive molecules such as TGF-β, IL-10, and indoleamine dioxygenase (IDO).
AB - CD8+ T regulatory cells (T regs) are elicited by unique antigen presenting cells during viral infections, by manipulation of co-stimulatory molecules, or in the development of tumors. CD8+ T regs display antigen-specificity, which is most exquisitely manifested by the HLA-E-restricted cytolytic CD8+ T regs in MS. There is evidence that some CD8+ T regs also express organ specificity. In many cases, IFN-γ is required for either the induction or expression of CD8+ T regs. CD8+ T regs can produce suppression directly by killing immune cells or indirectly by co-opting other cells to elaborate end-stage suppressive molecules such as TGF-β, IL-10, and indoleamine dioxygenase (IDO).
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U2 - 10.1016/j.coi.2008.02.003
DO - 10.1016/j.coi.2008.02.003
M3 - Review article
C2 - 18406591
AN - SCOPUS:45449108015
SN - 0952-7915
VL - 20
SP - 327
EP - 331
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -