Emerging concepts in CD8+ T regulatory cells

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

CD8+ T regulatory cells (T regs) are elicited by unique antigen presenting cells during viral infections, by manipulation of co-stimulatory molecules, or in the development of tumors. CD8+ T regs display antigen-specificity, which is most exquisitely manifested by the HLA-E-restricted cytolytic CD8+ T regs in MS. There is evidence that some CD8+ T regs also express organ specificity. In many cases, IFN-γ is required for either the induction or expression of CD8+ T regs. CD8+ T regs can produce suppression directly by killing immune cells or indirectly by co-opting other cells to elaborate end-stage suppressive molecules such as TGF-β, IL-10, and indoleamine dioxygenase (IDO).

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalCurrent Opinion in Immunology
Volume20
Issue number3
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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