Abstract
Increasing knowledge of drug resistance and side effects of currently approved agents, and of the biology of breast cancer, has given way to new treatment options that improve on previously available agents, or medications that target specific kinases and proteins associated with an oncogenic phenotype. This paper discusses new agents, including improved formulations of paclitaxel and epothilones, and molecularly targeted agents such as bevacizumab, sunitinib malate, pertuzumab, lapatinib, the mTOR inhibitors and farnesyl transferase inhibitors. Although endocrine therapy is a targeted therapy, it is not covered in this paper. These agents have increased excitement in the treatment of breast cancer and stand on the forefront of a potential improvement in quality of life and treatment options for patients afflicted with this deadly disease.
Original language | English (US) |
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Pages (from-to) | 489-501 |
Number of pages | 13 |
Journal | Expert Opinion on Emerging Drugs |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2006 |
Keywords
- Adjuvant therapy
- Bevacizumab
- Ixabepilone
- Lapatinib
- Pertuzumab
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)