Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver

Claudia Cicione, Chiara Degirolamo, Antonio Moschetta

Research output: Contribution to journalReview article

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Abstract

Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver.

Original languageEnglish (US)
Pages (from-to)2404-2411
Number of pages8
JournalHepatology
Volume56
Issue number6
DOIs
StatePublished - Dec 1 2012

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ASJC Scopus subject areas

  • Hepatology

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