Emerging role of high-mobility group box 1 (HMGB1) in liver diseases

Ruochan Chen, Wen Hou, Qiuhong Zhang, Rui Kang, Xue Gong Fan, Daolin Tang

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), is an abundant architectural chromosomal protein that has location-specific biological functions: within the nucleus as a DNA chaperone, within the cytosol to sustain autophagy and outside the cell as a DAMP molecule. Recent research indicates that aberrant activation of HMGB1 signaling can promote the onset of inflammatory and autoimmune diseases, raising interest in the development of therapeutic strategies to control their function. The importance of HMGB1 activation in various forms of liver disease in relation to liver damage, steatosis, inflammation, fibrosis, tumorigenesis and regeneration is discussed in this review.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalMolecular Medicine
Volume19
Issue number1
DOIs
StatePublished - Dec 2 2013
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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