Emerging Role of ISG15 in Antiviral Immunity

Brian Skaug; Zhijian J. Chen

doi:10.1016/j.cell.2010.09.033

Emerging Role of ISG15 in Antiviral Immunity

Brian Skaug, Zhijian J. Chen

Research output: Contribution to journal › Short survey › peer-review

176 Scopus citations

Abstract

Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	Cell
Volume	143
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2010.09.033
State	Published - Oct 15 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2010.09.033

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title = "Emerging Role of ISG15 in Antiviral Immunity",

abstract = "Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.",

author = "Brian Skaug and Chen, {Zhijian J.}",

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AU - Chen, Zhijian J.

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AB - Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.

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DO - 10.1016/j.cell.2010.09.033

M3 - Short survey

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VL - 143

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JO - Cell

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ER -

Emerging Role of ISG15 in Antiviral Immunity

Abstract

ASJC Scopus subject areas

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