Emerging Role of ISG15 in Antiviral Immunity

Brian Skaug, Zhijian J. Chen

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalCell
Volume143
Issue number2
DOIs
StatePublished - Oct 15 2010

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Ubiquitins
Viral Proteins
Virus Diseases
Interferons
Antiviral Agents
Immunity
Genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Emerging Role of ISG15 in Antiviral Immunity. / Skaug, Brian; Chen, Zhijian J.

In: Cell, Vol. 143, No. 2, 15.10.2010, p. 187-190.

Research output: Contribution to journalArticle

Skaug, Brian ; Chen, Zhijian J. / Emerging Role of ISG15 in Antiviral Immunity. In: Cell. 2010 ; Vol. 143, No. 2. pp. 187-190.
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