Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.

Original languageEnglish (US)
Pages (from-to)1120-1133
Number of pages14
JournalTrends in Immunology
Volume40
Issue number12
DOIs
StatePublished - Dec 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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