TY - JOUR
T1 - Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression
AU - Zhong, Fei
AU - Liang, Shuang
AU - Zhong, Zhenyu
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.
AB - Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.
UR - http://www.scopus.com/inward/record.url?scp=85075468224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075468224&partnerID=8YFLogxK
U2 - 10.1016/j.it.2019.10.008
DO - 10.1016/j.it.2019.10.008
M3 - Review article
C2 - 31744765
AN - SCOPUS:85075468224
SN - 1471-4906
VL - 40
SP - 1120
EP - 1133
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -