Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Murwan Omer, Ashanty Maggvie Melo, Lynne Kelly, Emma Jane Mac Dermott, Timothy Ronan Leahy, Orla Killeen, Ola DIdrik Saugstad, Rashmin C. Savani, Eleanor J. Molloy

Research output: Contribution to journalReview articlepeer-review

Abstract

Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.

Original languageEnglish (US)
Pages (from-to)545-554
Number of pages10
JournalNeonatology
Volume117
Issue number5
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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