Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Murwan Omer; Ashanty Maggvie Melo; Lynne Kelly; Emma Jane Mac Dermott; Timothy Ronan Leahy; Orla Killeen; Ola DIdrik Saugstad; Rashmin C. Savani; Eleanor J. Molloy

doi:10.1159/000507584

Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Murwan Omer, Ashanty Maggvie Melo, Lynne Kelly, Emma Jane Mac Dermott, Timothy Ronan Leahy, Orla Killeen, Ola DIdrik Saugstad, Rashmin C. Savani, Eleanor J. Molloy

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.

Original language	English (US)
Pages (from-to)	545-554
Number of pages	10
Journal	Neonatology
Volume	117
Issue number	5
DOIs	https://doi.org/10.1159/000507584
State	Published - Jan 2021

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

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title = "Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates",

abstract = "Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.",

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AU - Kelly, Lynne

AU - Mac Dermott, Emma Jane

AU - Leahy, Timothy Ronan

AU - Killeen, Orla

AU - Saugstad, Ola DIdrik

AU - Savani, Rashmin C.

AU - Molloy, Eleanor J.

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AB - Infection and persistent inflammation have a prominent role in the pathogenesis of brain injury and cerebral palsy, as well as other conditions associated with prematurity such as bronchopulmonary dysplasia. The NLRP3 inflammasome-interleukin (IL)-1β pathway has been extensively studied in adults and pre-clinical models, improving our understanding of innate immunity and offering an attractive therapeutic target that is already contributing to clinical management in many auto-inflammatory disorders. IL-1 blockade has transformed the course and outcome of conditions such as chronic infantile neurological, cutaneous, articular (CINCA/NOMID) syndrome. Inflammasome activation and upregulation has recently been implicated in neonatal brain and lung inflammatory disease and may be a novel therapeutic target.

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Emerging Role of the NLRP3 Inflammasome and Interleukin-1β in Neonates

Abstract

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