Emerging roles for myoglobin in the heart

Daniel J. Garry, Shane B. Kanatous, Pradeep P A Mammen

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalTrends in Cardiovascular Medicine
Volume13
Issue number3
DOIs
StatePublished - Apr 1 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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