TY - JOUR
T1 - Emerging roles of actin cytoskeleton regulating enzymes in drug addiction
T2 - Actin or reactin'?
AU - Rothenfluh, Adrian
AU - Cowan, Christopher W.
PY - 2013/8
Y1 - 2013/8
N2 - Neurons rely on their cytoskeleton to give them shape and stability, and on cytoskeletal dynamics for growth and synaptic plasticity. Because drug addiction is increasingly seen as the inappropriate learning of strongly reinforcing stimuli, the role of the cytoskeleton in shaping drug memories has been of increasing interest in recent years. Does the cytoskeleton have an active role in shaping these memories, and to what extent do alterations in the cytoskeleton reflect the acute actions of drug exposure, or homeostatic reactions to the chronic exposure to drugs of abuse? Here we will review recent advances in understanding the role of the cytoskeleton in the development of drug addiction, with a focus on actin filaments, as they have been studied in greater detail.
AB - Neurons rely on their cytoskeleton to give them shape and stability, and on cytoskeletal dynamics for growth and synaptic plasticity. Because drug addiction is increasingly seen as the inappropriate learning of strongly reinforcing stimuli, the role of the cytoskeleton in shaping drug memories has been of increasing interest in recent years. Does the cytoskeleton have an active role in shaping these memories, and to what extent do alterations in the cytoskeleton reflect the acute actions of drug exposure, or homeostatic reactions to the chronic exposure to drugs of abuse? Here we will review recent advances in understanding the role of the cytoskeleton in the development of drug addiction, with a focus on actin filaments, as they have been studied in greater detail.
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U2 - 10.1016/j.conb.2013.01.027
DO - 10.1016/j.conb.2013.01.027
M3 - Review article
C2 - 23428655
AN - SCOPUS:84881086575
SN - 0959-4388
VL - 23
SP - 507
EP - 512
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -