Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis

Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Stem or progenitor cells are an essential component for the development, homeostasis, expansion, and regeneration of many tissues. Within white adipose tissue (WAT) reside vascular-resident adipose progenitor cells (APCs) that can proliferate and differentiate into either white or beige/brite adipocytes, which may control adiposity. Recent studies have begun to show that APCs can be manipulated to control adiposity and counteract ‘diabesity’. However, much remains unknown about the identity of APCs and how they may control adiposity in response to homeostatic and external cues. Here, we discuss recent advances in our understanding of adipose progenitors and cover a range of topics, including the stem cell/progenitor lineage, their niche, their developmental and adult roles, and their role in cold-induced beige/brite adipocyte formation.

Original languageEnglish (US)
Pages (from-to)574-585
Number of pages12
JournalTrends in Endocrinology and Metabolism
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • adipose tissue
  • beige/brite adipocytes
  • niche
  • obesity
  • perivascular cells
  • stem cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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