Emerging roles of PKM2 in cell metabolism and cancer progression

Weibo Luo, Gregg L. Semenza

Research output: Contribution to journalReview article

171 Citations (Scopus)

Abstract

Increased conversion of glucose to lactate is a key feature of many cancer cells that promotes rapid growth. Pyruvate kinase M2 (PKM2) expression is increased and facilitates lactate production in cancer cells. Modulation of PKM2 catalytic activity also regulates the synthesis of DNA and lipids that are required for cell proliferation, and of NADPH that is required for redox homeostasis. In addition to its role as a pyruvate kinase, PKM2 also functions as a protein kinase and as a transcriptional coactivator. These biochemical activities are controlled by allosteric regulators and post-translational modifications of PKM2 that include acetylation, oxidation, phosphorylation, prolyl hydroxylation, and sumoylation. Given its pleiotropic effects on cancer biology, PKM2 represents an attractive target for cancer therapy.

Original languageEnglish (US)
Pages (from-to)560-566
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2012

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Pyruvate Kinase
Neoplasms
Lactic Acid
Sumoylation
Hydroxylation
Post Translational Protein Processing
Acetylation
NADP
Protein Kinases
Oxidation-Reduction
Homeostasis
Phosphorylation
Cell Proliferation
Lipids
Glucose
DNA
Growth

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Emerging roles of PKM2 in cell metabolism and cancer progression. / Luo, Weibo; Semenza, Gregg L.

In: Trends in Endocrinology and Metabolism, Vol. 23, No. 11, 01.11.2012, p. 560-566.

Research output: Contribution to journalReview article

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