Emerging roles of spliceosome in cancer and immunity

Hui Yang, Bruce Beutler, Duan-Wu Zhang Ph.D.

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered to be general cell “housekeeping” machinery, mutations in core components of the spliceosome frequently correlate with cell- or tissue-specific phenotypes and diseases. In this review, we expound the links between spliceosome mutations, aberrant splicing, and human cancers. Remarkably, spliceosome-targeted therapies (STTs) have become efficient anti-cancer strategies for cancer patients with splicing defects. We also highlight the links between spliceosome and immune signaling. Recent studies have shown that some spliceosome gene mutations can result in immune dysregulation and notable phenotypes due to mis-splicing of immune-related genes. Furthermore, several core spliceosome components harbor splicing-independent immune functions within the cell, expanding the functional repertoire of these diverse proteins.

Original languageEnglish (US)
Pages (from-to)559-579
Number of pages21
JournalProtein and Cell
Volume13
Issue number8
DOIs
StatePublished - Aug 2022

Keywords

  • cancer
  • immune dysregulation
  • innate immunity
  • spliceosome
  • splicing

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Drug Discovery
  • Cell Biology

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