TY - JOUR
T1 - Emerging roles of ubiquitin in transcription regulation
AU - Conaway, Ronald C.
AU - Brower, Christopher S.
AU - Conaway, Joan Weliky
PY - 2002/5/17
Y1 - 2002/5/17
N2 - Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate-dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.
AB - Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate-dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.
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U2 - 10.1126/science.1067466
DO - 10.1126/science.1067466
M3 - Review article
C2 - 12016299
AN - SCOPUS:0037123605
SN - 0036-8075
VL - 296
SP - 1254
EP - 1258
JO - Science
JF - Science
IS - 5571
ER -