Emerging roles of ubiquitin in transcription regulation

Ronald C. Conaway, Christopher S. Brower, Joan Weliky Conaway

Research output: Contribution to journalReview articlepeer-review

344 Scopus citations

Abstract

Ubiquitin is a small protein that was initially found to function as a tag that can be covalently attached to proteins to mark them for destruction by a multisubunit, adenosine 5′-triphosphate-dependent protease called the proteasome. Ubiquitin is now emerging as a key regulator of eukaryotic messenger RNA synthesis, a process that depends on the RNA synthetic enzyme RNA polymerase II and the transcription factors that control its activity. Ubiquitin controls messenger RNA synthesis not only by mechanisms involving ubiquitin-dependent destruction of transcription factors by the proteasome, but also by an intriguing collection of previously unknown and unanticipated mechanisms that appear to be independent of the proteasome.

Original languageEnglish (US)
Pages (from-to)1254-1258
Number of pages5
JournalScience
Volume296
Issue number5571
DOIs
StatePublished - May 17 2002
Externally publishedYes

ASJC Scopus subject areas

  • General

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