Emerging Targets of Diuretic Therapy

C. J. Cheng, A. R. Rodan, C. L. Huang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Diuretics are commonly prescribed for treatment in patients with hypertension, edema, or heart failure. Studies on hypertensive and salt-losing disorders and on urea transporters have contributed to better understanding of mechanisms of renal salt and water reabsorption and their regulation. Proteins involved in the regulatory pathways are emerging targets for diuretic and aquaretic therapy. Integrative high-throughput screening, protein structure analysis, and chemical modification have identified promising agents for preclinical testing in animals. These include WNK-SPAK inhibitors, ClC-K channel antagonists, ROMK channel antagonists, and pendrin and urea transporter inhibitors. We discuss the potential advantages and side effects of these potential diuretics.

Original languageEnglish (US)
Pages (from-to)420-435
Number of pages16
JournalClinical Pharmacology and Therapeutics
Volume102
Issue number3
DOIs
StatePublished - Sep 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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