Emerging themes in neuronal activity-dependent gene expression

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-acting elements within the promoters of immediate-early genes, the corresponding transcription factors that bind these elements, and the roles of major activity-regulated signaling pathways. However, our emphasis is on new studies that have revealed an important role for epigenetic and topological mechanisms, including enhancer-promoter interactions, enhancer RNAs (eRNAs), and activity-induced DNA breaks, that have emerged as important factors that govern the temporal dynamics of activity-induced gene transcription.

Original languageEnglish (US)
JournalMolecular and Cellular Neuroscience
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Immediate-Early Genes
Genetic Transcription
Gene Expression
DNA Breaks
Epigenomics
Genes
Transcription Factors
RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

@article{31ccd1973ce34709b387152fc4e0d8b9,
title = "Emerging themes in neuronal activity-dependent gene expression",
abstract = "In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-acting elements within the promoters of immediate-early genes, the corresponding transcription factors that bind these elements, and the roles of major activity-regulated signaling pathways. However, our emphasis is on new studies that have revealed an important role for epigenetic and topological mechanisms, including enhancer-promoter interactions, enhancer RNAs (eRNAs), and activity-induced DNA breaks, that have emerged as important factors that govern the temporal dynamics of activity-induced gene transcription.",
author = "Ram Madabhushi and Kim, {Tae Kyung}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.mcn.2017.11.009",
language = "English (US)",
journal = "Molecular and Cellular Neuroscience",
issn = "1044-7431",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Emerging themes in neuronal activity-dependent gene expression

AU - Madabhushi, Ram

AU - Kim, Tae Kyung

PY - 2017/1/1

Y1 - 2017/1/1

N2 - In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-acting elements within the promoters of immediate-early genes, the corresponding transcription factors that bind these elements, and the roles of major activity-regulated signaling pathways. However, our emphasis is on new studies that have revealed an important role for epigenetic and topological mechanisms, including enhancer-promoter interactions, enhancer RNAs (eRNAs), and activity-induced DNA breaks, that have emerged as important factors that govern the temporal dynamics of activity-induced gene transcription.

AB - In this review, we attempt to discuss emerging themes in the regulation of neuronal activity-regulated genes, focusing primarily on an important subset of immediate-early genes. We first discuss earlier studies that have illuminated the role of cis-acting elements within the promoters of immediate-early genes, the corresponding transcription factors that bind these elements, and the roles of major activity-regulated signaling pathways. However, our emphasis is on new studies that have revealed an important role for epigenetic and topological mechanisms, including enhancer-promoter interactions, enhancer RNAs (eRNAs), and activity-induced DNA breaks, that have emerged as important factors that govern the temporal dynamics of activity-induced gene transcription.

UR - http://www.scopus.com/inward/record.url?scp=85039432856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039432856&partnerID=8YFLogxK

U2 - 10.1016/j.mcn.2017.11.009

DO - 10.1016/j.mcn.2017.11.009

M3 - Article

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

SN - 1044-7431

ER -