Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins

Cristiaan D. Ochoa, Ron Balczon, Troy Stevens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endothelium forms the inner lining of all blood and lymphatic vessels. Due to this strategic localization, endothelium is a major regulator of numerous physiological functions including blood coagulation, vascular tone, vascular permeability, angiogenesis, lipid metabolism, inflammation, and leukocyte trafficking. In the lung, microvascular endothelium forms a highly restrictive barrier to allow proper gas exchange (Chetham et al. 1999, Jacobson and Garcia 2010, Kelly et al. 1998, Ofori-Acquah et al. 2008, Stevens et al. 2008). Inflammatory mediators and vascular permeability-increasing compounds cause retraction of cell borders and inter-endothelial gaps by reorganizing the endothelial cytoskeleton, cell-cell, and cell matrix interactions, an effect that causes alveolar edema and impairs gas exchange.

Original languageEnglish (US)
Title of host publicationEndothelial Cytoskeleton
PublisherCRC Press
Pages27-52
Number of pages26
ISBN (Electronic)9781466590366
ISBN (Print)9781466590359
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Microtubule-Associated Proteins
Endothelial cells
Microtubules
Endothelium
Blood
Endothelial Cells
Gases
Capillary Permeability
Lung
Blood Vessels
Coagulation
Linings
Lymphatic Vessels
Blood Coagulation
Cytoskeleton
Lipid Metabolism
Cell Communication
Edema
Leukocytes
Inflammation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ochoa, C. D., Balczon, R., & Stevens, T. (2013). Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins. In Endothelial Cytoskeleton (pp. 27-52). CRC Press.

Emerging themes on pulmonary microvascular endothelial cell : Microtubules and microtubule associated proteins. / Ochoa, Cristiaan D.; Balczon, Ron; Stevens, Troy.

Endothelial Cytoskeleton. CRC Press, 2013. p. 27-52.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ochoa, CD, Balczon, R & Stevens, T 2013, Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins. in Endothelial Cytoskeleton. CRC Press, pp. 27-52.
Ochoa CD, Balczon R, Stevens T. Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins. In Endothelial Cytoskeleton. CRC Press. 2013. p. 27-52
Ochoa, Cristiaan D. ; Balczon, Ron ; Stevens, Troy. / Emerging themes on pulmonary microvascular endothelial cell : Microtubules and microtubule associated proteins. Endothelial Cytoskeleton. CRC Press, 2013. pp. 27-52
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