Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins

Cristiaan D. Ochoa, Ron Balczon, Troy Stevens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endothelium forms the inner lining of all blood and lymphatic vessels. Due to this strategic localization, endothelium is a major regulator of numerous physiological functions including blood coagulation, vascular tone, vascular permeability, angiogenesis, lipid metabolism, inflammation, and leukocyte trafficking. In the lung, microvascular endothelium forms a highly restrictive barrier to allow proper gas exchange (Chetham et al. 1999, Jacobson and Garcia 2010, Kelly et al. 1998, Ofori-Acquah et al. 2008, Stevens et al. 2008). Inflammatory mediators and vascular permeability-increasing compounds cause retraction of cell borders and inter-endothelial gaps by reorganizing the endothelial cytoskeleton, cell-cell, and cell matrix interactions, an effect that causes alveolar edema and impairs gas exchange.

Original languageEnglish (US)
Title of host publicationEndothelial Cytoskeleton
PublisherCRC Press
Pages27-52
Number of pages26
ISBN (Electronic)9781466590366
ISBN (Print)9781466590359
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Ochoa, C. D., Balczon, R., & Stevens, T. (2013). Emerging themes on pulmonary microvascular endothelial cell: Microtubules and microtubule associated proteins. In Endothelial Cytoskeleton (pp. 27-52). CRC Press.