TY - JOUR
T1 - Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder
T2 - Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study
AU - Ruocco, Anthony C.
AU - Reilly, James L.
AU - Rubin, Leah H.
AU - Daros, Alex R.
AU - Gershon, Elliot S.
AU - Tamminga, Carol A.
AU - Pearlson, Godfrey D.
AU - Hill, S. Kristian
AU - Keshavan, Matcheri S.
AU - Gur, Ruben C.
AU - Sweeney, John A.
N1 - Funding Information:
This work was supported by the National Institute of Mental Health at the National Institutes of Health (grant numbers MH078113 , MH077945 , MH077852 , MH077851 , MH077862 , MH072767 , and MH083888 ), Canadian Institutes of Health Research (New Investigator Salary Award, grant number MSH-130177 to A.C.R.), Social Sciences and Humanities Research Council of Canada (Joseph-Armand Bombardier CGS Doctoral Scholarship to A.R.D.), and the Brain and Behavior Research Foundation (NARSAD Young Investigator Grant to L.H.R.).
PY - 2014
Y1 - 2014
N2 - Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.
AB - Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.
KW - Bipolar disorder
KW - Emotion recognition
KW - Family study
KW - Psychosis
KW - Schizoaffective disorder
KW - Schizophrenia
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U2 - 10.1016/j.schres.2014.07.001
DO - 10.1016/j.schres.2014.07.001
M3 - Article
C2 - 25052782
AN - SCOPUS:84906933641
SN - 0920-9964
VL - 158
SP - 105
EP - 112
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -