Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder

Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study

Anthony C. Ruocco, James L. Reilly, Leah H. Rubin, Alex R. Daros, Elliot S. Gershon, Carol A. Tamminga, Godfrey D. Pearlson, S. Kristian Hill, Matcheri S. Keshavan, Ruben C. Gur, John A. Sweeney

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalSchizophrenia Research
Volume158
Issue number1-3
DOIs
StatePublished - 2014

Fingerprint

Bipolar Disorder
Psychotic Disorders
Schizophrenia
Emotions
Phenotype
Personality Disorders
Happiness
Aptitude
Anger
Fear

Keywords

  • Bipolar disorder
  • Emotion recognition
  • Family study
  • Psychosis
  • Schizoaffective disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder : Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. / Ruocco, Anthony C.; Reilly, James L.; Rubin, Leah H.; Daros, Alex R.; Gershon, Elliot S.; Tamminga, Carol A.; Pearlson, Godfrey D.; Hill, S. Kristian; Keshavan, Matcheri S.; Gur, Ruben C.; Sweeney, John A.

In: Schizophrenia Research, Vol. 158, No. 1-3, 2014, p. 105-112.

Research output: Contribution to journalArticle

Ruocco, Anthony C. ; Reilly, James L. ; Rubin, Leah H. ; Daros, Alex R. ; Gershon, Elliot S. ; Tamminga, Carol A. ; Pearlson, Godfrey D. ; Hill, S. Kristian ; Keshavan, Matcheri S. ; Gur, Ruben C. ; Sweeney, John A. / Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder : Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study. In: Schizophrenia Research. 2014 ; Vol. 158, No. 1-3. pp. 105-112.
@article{ceff073647f1454e8bb08ef9cd3e2fa3,
title = "Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study",
abstract = "Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.",
keywords = "Bipolar disorder, Emotion recognition, Family study, Psychosis, Schizoaffective disorder, Schizophrenia",
author = "Ruocco, {Anthony C.} and Reilly, {James L.} and Rubin, {Leah H.} and Daros, {Alex R.} and Gershon, {Elliot S.} and Tamminga, {Carol A.} and Pearlson, {Godfrey D.} and Hill, {S. Kristian} and Keshavan, {Matcheri S.} and Gur, {Ruben C.} and Sweeney, {John A.}",
year = "2014",
doi = "10.1016/j.schres.2014.07.001",
language = "English (US)",
volume = "158",
pages = "105--112",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Emotion recognition deficits in schizophrenia-spectrum disorders and psychotic bipolar disorder

T2 - Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study

AU - Ruocco, Anthony C.

AU - Reilly, James L.

AU - Rubin, Leah H.

AU - Daros, Alex R.

AU - Gershon, Elliot S.

AU - Tamminga, Carol A.

AU - Pearlson, Godfrey D.

AU - Hill, S. Kristian

AU - Keshavan, Matcheri S.

AU - Gur, Ruben C.

AU - Sweeney, John A.

PY - 2014

Y1 - 2014

N2 - Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.

AB - Background: Difficulty recognizing facial emotions is an important social-cognitive deficit associated with psychotic disorders. It also may reflect a familial risk for psychosis in schizophrenia-spectrum disorders and bipolar disorder. Objective: The objectives of this study from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium were to: 1) compare emotion recognition deficits in schizophrenia, schizoaffective disorder and bipolar disorder with psychosis, 2) determine the familiality of emotion recognition deficits across these disorders, and 3) evaluate emotion recognition deficits in nonpsychotic relatives with and without elevated Cluster A and Cluster B personality disorder traits. Method: Participants included probands with schizophrenia (n=. 297), schizoaffective disorder (depressed type, n=. 61; bipolar type, n=. 69), bipolar disorder with psychosis (n=. 248), their first-degree relatives (n=. 332, n=. 69, n=. 154, and n=. 286, respectively) and healthy controls (n=. 380). All participants completed the Penn Emotion Recognition Test, a standardized measure of facial emotion recognition assessing four basic emotions (happiness, sadness, anger and fear) and neutral expressions (no emotion). Results: Compared to controls, emotion recognition deficits among probands increased progressively from bipolar disorder to schizoaffective disorder to schizophrenia. Proband and relative groups showed similar deficits perceiving angry and neutral faces, whereas deficits on fearful, happy and sad faces were primarily isolated to schizophrenia probands. Even non-psychotic relatives without elevated Cluster A or Cluster B personality disorder traits showed deficits on neutral and angry faces. Emotion recognition ability was moderately familial only in schizophrenia families. Conclusions: Emotion recognition deficits are prominent but somewhat different across psychotic disorders. These deficits are reflected to a lesser extent in relatives, particularly on angry and neutral faces. Deficits were evident in non-psychotic relatives even without elevated personality disorder traits. Deficits in facial emotion recognition may reflect an important social-cognitive deficit in patients with psychotic disorders.

KW - Bipolar disorder

KW - Emotion recognition

KW - Family study

KW - Psychosis

KW - Schizoaffective disorder

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84906933641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906933641&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2014.07.001

DO - 10.1016/j.schres.2014.07.001

M3 - Article

VL - 158

SP - 105

EP - 112

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -