@article{79c882fb33d6414f85a192005d18dc18,
title = "Enantiomeric separation of biaryl atropisomers using cyclofructan based chiral stationary phases",
abstract = "Normal phase chiral HPLC methods are presented for the enantiomeric separation of 30 biaryl atropisomers including 18 new compounds recently produced via a novel synthetic approach. Three new cyclofructan based chiral stationary phases were evaluated. Separations were achieved for all but six analytes and the LARIHC{\texttrademark} CF6-P alone provided 15 baseline separations. Effects of polar modifiers and temperature effects also were studied. Apparent thermodynamic parameters were determined by van't Hoff plots. Preparative scale methods were developed and employed resulting in the first ever isolation of these novel atropisomers in their pure enantiomeric form. Insights into the mechanism of retention and chiral discrimination are presented.",
keywords = "Atropisomers, Biaryls, Chiral HPLC, Cyclofructans, Preparative HPLC",
author = "Woods, {Ross M.} and Patel, {Darshan C.} and Yeeun Lim and Breitbach, {Zachary S.} and Hongyin Gao and Craig Keene and Gongqiang Li and L{\'a}szl{\'o} K{\"u}rti and Armstrong, {Daniel W.}",
note = "Funding Information: L.K. gratefully acknowledges the generous financial support of the UT Southwestern Endowed Scholars in Biomedical Research Program (W.W. Caruth Jr., Endowed Scholarship in Biomedical Research), the Robert A. Welch Foundation (Grant I-1764 ), the ACS-PRF (Grant 51707-DNI1 ) and the American Cancer Society & Simmons Cancer Center Institutional Research Grant (New Investigator Award in Cancer Research, ACS-IRG 02-196 ). Funding Information: Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number R44GM103359 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. ",
year = "2014",
month = aug,
day = "29",
doi = "10.1016/j.chroma.2014.04.080",
language = "English (US)",
volume = "1357",
pages = "172--181",
journal = "Journal of Chromatography A",
issn = "0021-9673",
publisher = "Elsevier",
}