Abstract
Enantioselective (formal) aza-Diels-Alder reactions between acylhydrazones and non-Danishefsky-type dienes have been developed. The reactions are promoted by a simple and economical chiral silicon Lewis acid and are typically conducted at ambient temperature. Both glyoxylate- and aliphatic aldehyde-derived hydrazones may be employed, as may variously substituted dienes, leading to the synthesis of a diverse array of tetrahydropyridines with good to excellent levels of enantioselectivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10248-10250 |
| Number of pages | 3 |
| Journal | Journal of the American Chemical Society |
| Volume | 132 |
| Issue number | 30 |
| DOIs | |
| State | Published - Aug 4 2010 |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry