Abstract
An enantioselective strategy for the synthesis of tetracyclic motif 5, representing the northern fragment of norzoanthamine, is presented. Key to the strategy is the use of two asymmetric Robinson annulation reactions that produce the tricyclic ABC ring system with excellent stereoselectivity. Further functionalization at the periphery of the C ring produces compound 5 containing six contiguous stereocenters of the natural product.
Original language | English (US) |
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Pages (from-to) | 3308-3311 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry