Enantiospecific synthesis of 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites

J R Falck, Sun Lumin, Sang Gyeong Lee, Bertrand Heckmann, Charles Mioskowski, Armando Karara, Jorge Capdevila

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The title bioactive eicosanoids were prepared from dimethyl L-malate by a convergent strategy exploiting the differential reactivity of ethereal dialkylcuprates towards tosylates versus bromides.

Original languageEnglish (US)
Pages (from-to)4893-4896
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number34
DOIs
StatePublished - Aug 18 1992

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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