Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

R. K. Bhatt, J R Falck, S. Nigam

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number3-4
DOIs
StatePublished - Jan 15 1998

Fingerprint

Ribose
Enantiomers
Metabolites
Arachidonic Acid
Aldehydes
Salts
3-hydroxy-5,8,11,14-eicosatetraenoic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid. / Bhatt, R. K.; Falck, J R; Nigam, S.

In: Tetrahedron Letters, Vol. 39, No. 3-4, 15.01.1998, p. 249-252.

Research output: Contribution to journalArticle

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