Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

R. K. Bhatt; J R Falck; S. Nigam

doi:10.1016/S0040-4039(97)10565-2

Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

R. K. Bhatt, J R Falck, S. Nigam

Biochemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

Original language	English (US)
Pages (from-to)	249-252
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	3-4
DOIs	https://doi.org/10.1016/S0040-4039(97)10565-2
State	Published - Jan 15 1998

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid",

abstract = "The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.",

author = "Bhatt, {R. K.} and Falck, {J R} and S. Nigam",

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AU - Bhatt, R. K.

AU - Falck, J R

AU - Nigam, S.

PY - 1998/1/15

Y1 - 1998/1/15

N2 - The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

AB - The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 3-4

ER -

Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

Abstract

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