TY - JOUR
T1 - Endemic pemphigus foliaceus (fogo selvagem) in Native Americans from Brazil
AU - Friedman, Horacio
AU - Campbell, Iphis
AU - Rocha-Alvarez, Rosicler
AU - Ferrari, Iris
AU - Coimbra, Carlos E A
AU - Moraes, Jose R.
AU - Flowers, Nancy M.
AU - Stastny, Peter
AU - Fernandez-Viña, Marcelo
AU - Olague-Alcala, Monica
AU - Diaz, Luis A.
N1 - Funding Information:
Supported by The Conselho National de Pesquisa e Desenvolvimento do Brasil (grants 401127/89-3 and 451129/93-g); The Coordena-doria de Aperfeicoamento de Pessoal de Ensino Superior do Brasil; The Fundacad National do Indio no Brasil and the Wenner-Gren Foundation for Anthropological Research and by grants R37 AR32081, ROl AR32599,POI-AI-2327, ROl HL47145 and T32 AR07577 from the National Institutes Health and by the Depart-ment of Veterans Affairs.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1995/6
Y1 - 1995/6
N2 - Background: Fogo selvagem (FS) is an autoimmune disease that is endemic in certain regions of Brazil and appears to be precipitated by an environmental factor. Objective: Our purpose was to confirm the occurrence and prevalence of FS in a population of Xavante Indians living in an endemic region of central Brazil. Methods: Clinical, anthropologic, and immunologic studies were carried out in patients and in normal inhabitants of the Pimentel Barbosa Indian Reservation, Mato Grosso, Brazil. Results: FS was identified and confirmed in 10 patients from a patient pool of 295 with various skin diseases. The Xavante settlement has a total population of 746. Anti-desmoglein 1 autoantibodies were detected in all patients with FS and were absent from more than 300 serum samples collected from randomly selected unaffected persons. Conclusion: FS is strongly linked to outdoor activities and is largely restricted to immunogenetically predisposed persons. FS appears to have been endemic in certain regions of South America for several centuries.
AB - Background: Fogo selvagem (FS) is an autoimmune disease that is endemic in certain regions of Brazil and appears to be precipitated by an environmental factor. Objective: Our purpose was to confirm the occurrence and prevalence of FS in a population of Xavante Indians living in an endemic region of central Brazil. Methods: Clinical, anthropologic, and immunologic studies were carried out in patients and in normal inhabitants of the Pimentel Barbosa Indian Reservation, Mato Grosso, Brazil. Results: FS was identified and confirmed in 10 patients from a patient pool of 295 with various skin diseases. The Xavante settlement has a total population of 746. Anti-desmoglein 1 autoantibodies were detected in all patients with FS and were absent from more than 300 serum samples collected from randomly selected unaffected persons. Conclusion: FS is strongly linked to outdoor activities and is largely restricted to immunogenetically predisposed persons. FS appears to have been endemic in certain regions of South America for several centuries.
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U2 - 10.1016/0190-9622(95)91330-0
DO - 10.1016/0190-9622(95)91330-0
M3 - Article
C2 - 7751464
AN - SCOPUS:0029061706
SN - 0190-9622
VL - 32
SP - 949
EP - 956
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -