Endo-selective pd-catalyzed silyl methyl heck reaction

Marvin Parasram, Viktor O. Iaroshenko, Vladimir Gevorgyan

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

A palladium (Pd)-catalyzed endo-selective Heck reaction of iodomethylsilyl ethers of phenols and aliphatic alkenols has been developed. Mechanistic studies reveal that this silyl methyl Heck reaction operates via a hybrid Pd-radical process and that the silicon atom is crucial for the observed endo selectivity. The obtained allylic silyloxycycles were further oxidized into (Z)-alkenyldiols.

Original languageEnglish (US)
Pages (from-to)17926-17929
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number52
DOIs
StatePublished - Dec 31 2014
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Endo-selective pd-catalyzed silyl methyl heck reaction'. Together they form a unique fingerprint.

  • Cite this