Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Matthew J. Potthoff; Steven A. Kliewer; David J. Mangelsdorf

doi:10.1101/gad.184788.111

Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Matthew J. Potthoff, Steven A. Kliewer, David J. Mangelsdorf

Research output: Contribution to journal › Review article › peer-review

361 Scopus citations

Abstract

We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.

Original language	English (US)
Pages (from-to)	312-324
Number of pages	13
Journal	Genes and Development
Volume	26
Issue number	4
DOIs	https://doi.org/10.1101/gad.184788.111
State	Published - Feb 15 2012

Keywords

Bile acids
Diabetes
FGF15
FGF19
FGF21
Obesity

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.184788.111

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abstract = "We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.",

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AU - Mangelsdorf, David J.

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AB - We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.

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KW - FGF21

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Endocrine fibroblast growth factors 15/19 and 21: From feast to famine

Abstract

Keywords

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