Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9

Nawal Bendris, Sandra L. Schmid

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Sorting nexin (SNX)9 was first discovered as an endocytic accessory protein involved in clathrin-mediated endocytosis. However, recent data suggest that SNX9 is a multifunctional scaffold that coordinates membrane trafficking and remodeling with changes in actin dynamics to affect diverse cellular processes. Here, we review the accumulated knowledge on SNX9 with an emphasis on its recently identified roles in clathrin-independent endocytic pathways, cell invasion, and cell division, which have implications for SNX9 function in human disease, including cancer.

Original languageEnglish (US)
Pages (from-to)189-200
Number of pages12
JournalTrends in Cell Biology
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • actin
  • cancer
  • cell motility
  • inflammation
  • invadosome
  • mitosis
  • RhoGTPase

ASJC Scopus subject areas

  • Cell Biology

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