Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns

J. Wells Logan, Elizabeth N. Allred, Raina N. Fichorova, Stephen Engelke, Olaf Dammann, Alan Leviton, Kathleen Lee, Anne McGovern, Jill Gambardella, Susan Ursprung, Ruth Blomquist, Bhavesh Shah, Karen Christianson, Camilia R. Martin, Linda J. Van Marter, Robert M. Insoft, Jennifer G. Wilson, Maureen Pimental, Cynthia Cole, John M. Fiascone & 29 others Janet Madden, Ellen Nylen, Anne Furey, Francis Bednarek, Mary Naples, Beth Powers, Richard Ehrenkranz, Joanne Williams, Elaine Romano, T. Michael O'Shea, Debbie Gordon, Teresa Harold, Stephen C. Engelke, Sherry Moseley, Donna Pare, Carl Bose, Gennie Bose, Mariel Poortenga, Dinah Sutton, Carolyn Solomon, Nigel Paneth, Padmani Karna, Madeleine Lenski, Michael D. Schreiber, Grace Yoon, Daniel Batton, Beth Kring, Ken Wood, Deborah Hirtz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation. Data from the ELGAN Study allowed us to evaluate relationships between endogenous erythropoietin and 25 inflammation-related proteins in extremely premature newborns. Methods: We measured the concentrations of 25 inflammation-related proteins and of erythropoietin in blood spots collected on postnatal days 1, 7, and 14 from 936 infants born before 28. weeks gestation. We calculated the odds that infants with an inflammation-related protein in the highest quartile for gestational age and collection day had an erythropoietin concentration in the highest or lowest quartile. Results: The proportion of children with inflammation-associated protein concentrations in the top quartile tended to increase monotonically with increasing quartile of EPO concentrations on 2 of the 3. days assessed. To a large extent, on each of the 3. days assessed, the odds ratios for an erythropoietin concentration in the top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Conclusions: Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or reducing inflammation, or by promoting an anti-injury or repair capability.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalCytokine
Volume69
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Erythropoietin
Newborn Infant
Inflammation
Proteins
Fetal Development
Erythropoiesis
Growth and Development
Gestational Age
Glycoproteins
Repair
Blood
Odds Ratio
Pregnancy
Wounds and Injuries

Keywords

  • Acute-phase
  • Cytokine
  • Infant
  • Premature
  • Protein

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Wells Logan, J., Allred, E. N., Fichorova, R. N., Engelke, S., Dammann, O., Leviton, A., ... Hirtz, D. (2014). Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns. Cytokine, 69(1), 22-28. https://doi.org/10.1016/j.cyto.2014.04.009

Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns. / Wells Logan, J.; Allred, Elizabeth N.; Fichorova, Raina N.; Engelke, Stephen; Dammann, Olaf; Leviton, Alan; Lee, Kathleen; McGovern, Anne; Gambardella, Jill; Ursprung, Susan; Blomquist, Ruth; Shah, Bhavesh; Christianson, Karen; Martin, Camilia R.; Van Marter, Linda J.; Insoft, Robert M.; Wilson, Jennifer G.; Pimental, Maureen; Cole, Cynthia; Fiascone, John M.; Madden, Janet; Nylen, Ellen; Furey, Anne; Bednarek, Francis; Naples, Mary; Powers, Beth; Ehrenkranz, Richard; Williams, Joanne; Romano, Elaine; O'Shea, T. Michael; Gordon, Debbie; Harold, Teresa; Engelke, Stephen C.; Moseley, Sherry; Pare, Donna; Bose, Carl; Bose, Gennie; Poortenga, Mariel; Sutton, Dinah; Solomon, Carolyn; Paneth, Nigel; Karna, Padmani; Lenski, Madeleine; Schreiber, Michael D.; Yoon, Grace; Batton, Daniel; Kring, Beth; Wood, Ken; Hirtz, Deborah.

In: Cytokine, Vol. 69, No. 1, 2014, p. 22-28.

Research output: Contribution to journalArticle

Wells Logan, J, Allred, EN, Fichorova, RN, Engelke, S, Dammann, O, Leviton, A, Lee, K, McGovern, A, Gambardella, J, Ursprung, S, Blomquist, R, Shah, B, Christianson, K, Martin, CR, Van Marter, LJ, Insoft, RM, Wilson, JG, Pimental, M, Cole, C, Fiascone, JM, Madden, J, Nylen, E, Furey, A, Bednarek, F, Naples, M, Powers, B, Ehrenkranz, R, Williams, J, Romano, E, O'Shea, TM, Gordon, D, Harold, T, Engelke, SC, Moseley, S, Pare, D, Bose, C, Bose, G, Poortenga, M, Sutton, D, Solomon, C, Paneth, N, Karna, P, Lenski, M, Schreiber, MD, Yoon, G, Batton, D, Kring, B, Wood, K & Hirtz, D 2014, 'Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns', Cytokine, vol. 69, no. 1, pp. 22-28. https://doi.org/10.1016/j.cyto.2014.04.009
Wells Logan, J. ; Allred, Elizabeth N. ; Fichorova, Raina N. ; Engelke, Stephen ; Dammann, Olaf ; Leviton, Alan ; Lee, Kathleen ; McGovern, Anne ; Gambardella, Jill ; Ursprung, Susan ; Blomquist, Ruth ; Shah, Bhavesh ; Christianson, Karen ; Martin, Camilia R. ; Van Marter, Linda J. ; Insoft, Robert M. ; Wilson, Jennifer G. ; Pimental, Maureen ; Cole, Cynthia ; Fiascone, John M. ; Madden, Janet ; Nylen, Ellen ; Furey, Anne ; Bednarek, Francis ; Naples, Mary ; Powers, Beth ; Ehrenkranz, Richard ; Williams, Joanne ; Romano, Elaine ; O'Shea, T. Michael ; Gordon, Debbie ; Harold, Teresa ; Engelke, Stephen C. ; Moseley, Sherry ; Pare, Donna ; Bose, Carl ; Bose, Gennie ; Poortenga, Mariel ; Sutton, Dinah ; Solomon, Carolyn ; Paneth, Nigel ; Karna, Padmani ; Lenski, Madeleine ; Schreiber, Michael D. ; Yoon, Grace ; Batton, Daniel ; Kring, Beth ; Wood, Ken ; Hirtz, Deborah. / Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns. In: Cytokine. 2014 ; Vol. 69, No. 1. pp. 22-28.
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abstract = "Introduction: Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation. Data from the ELGAN Study allowed us to evaluate relationships between endogenous erythropoietin and 25 inflammation-related proteins in extremely premature newborns. Methods: We measured the concentrations of 25 inflammation-related proteins and of erythropoietin in blood spots collected on postnatal days 1, 7, and 14 from 936 infants born before 28. weeks gestation. We calculated the odds that infants with an inflammation-related protein in the highest quartile for gestational age and collection day had an erythropoietin concentration in the highest or lowest quartile. Results: The proportion of children with inflammation-associated protein concentrations in the top quartile tended to increase monotonically with increasing quartile of EPO concentrations on 2 of the 3. days assessed. To a large extent, on each of the 3. days assessed, the odds ratios for an erythropoietin concentration in the top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Conclusions: Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or reducing inflammation, or by promoting an anti-injury or repair capability.",
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T1 - Endogenous erythropoietin varies significantly with inflammation-related proteins in extremely premature newborns

AU - Wells Logan, J.

AU - Allred, Elizabeth N.

AU - Fichorova, Raina N.

AU - Engelke, Stephen

AU - Dammann, Olaf

AU - Leviton, Alan

AU - Lee, Kathleen

AU - McGovern, Anne

AU - Gambardella, Jill

AU - Ursprung, Susan

AU - Blomquist, Ruth

AU - Shah, Bhavesh

AU - Christianson, Karen

AU - Martin, Camilia R.

AU - Van Marter, Linda J.

AU - Insoft, Robert M.

AU - Wilson, Jennifer G.

AU - Pimental, Maureen

AU - Cole, Cynthia

AU - Fiascone, John M.

AU - Madden, Janet

AU - Nylen, Ellen

AU - Furey, Anne

AU - Bednarek, Francis

AU - Naples, Mary

AU - Powers, Beth

AU - Ehrenkranz, Richard

AU - Williams, Joanne

AU - Romano, Elaine

AU - O'Shea, T. Michael

AU - Gordon, Debbie

AU - Harold, Teresa

AU - Engelke, Stephen C.

AU - Moseley, Sherry

AU - Pare, Donna

AU - Bose, Carl

AU - Bose, Gennie

AU - Poortenga, Mariel

AU - Sutton, Dinah

AU - Solomon, Carolyn

AU - Paneth, Nigel

AU - Karna, Padmani

AU - Lenski, Madeleine

AU - Schreiber, Michael D.

AU - Yoon, Grace

AU - Batton, Daniel

AU - Kring, Beth

AU - Wood, Ken

AU - Hirtz, Deborah

PY - 2014

Y1 - 2014

N2 - Introduction: Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation. Data from the ELGAN Study allowed us to evaluate relationships between endogenous erythropoietin and 25 inflammation-related proteins in extremely premature newborns. Methods: We measured the concentrations of 25 inflammation-related proteins and of erythropoietin in blood spots collected on postnatal days 1, 7, and 14 from 936 infants born before 28. weeks gestation. We calculated the odds that infants with an inflammation-related protein in the highest quartile for gestational age and collection day had an erythropoietin concentration in the highest or lowest quartile. Results: The proportion of children with inflammation-associated protein concentrations in the top quartile tended to increase monotonically with increasing quartile of EPO concentrations on 2 of the 3. days assessed. To a large extent, on each of the 3. days assessed, the odds ratios for an erythropoietin concentration in the top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Conclusions: Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or reducing inflammation, or by promoting an anti-injury or repair capability.

AB - Introduction: Erythropoietin, a pluripotent glycoprotein essential for erythropoiesis, fetal growth, and development, has recently been implicated in innate immune regulation. Data from the ELGAN Study allowed us to evaluate relationships between endogenous erythropoietin and 25 inflammation-related proteins in extremely premature newborns. Methods: We measured the concentrations of 25 inflammation-related proteins and of erythropoietin in blood spots collected on postnatal days 1, 7, and 14 from 936 infants born before 28. weeks gestation. We calculated the odds that infants with an inflammation-related protein in the highest quartile for gestational age and collection day had an erythropoietin concentration in the highest or lowest quartile. Results: The proportion of children with inflammation-associated protein concentrations in the top quartile tended to increase monotonically with increasing quartile of EPO concentrations on 2 of the 3. days assessed. To a large extent, on each of the 3. days assessed, the odds ratios for an erythropoietin concentration in the top quartile were significantly elevated among those with an inflammation-related protein concentration in the top quartile. Conclusions: Our findings suggest that in very preterm newborns, circulating levels of endogenous erythropoietin vary significantly with circulating levels of inflammation-related proteins. Elevation of endogenous erythropoietin might not be an epiphenomenon, but instead might contribute to subsequent events, by either promoting or reducing inflammation, or by promoting an anti-injury or repair capability.

KW - Acute-phase

KW - Cytokine

KW - Infant

KW - Premature

KW - Protein

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U2 - 10.1016/j.cyto.2014.04.009

DO - 10.1016/j.cyto.2014.04.009

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JF - Cytokine

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