Endoluminal and Interstitial Brachytherapy for the Treatment of Gastrointestinal Malignancies: a Systematic Review

Sujana Gottumukkala, Vasu Tumati, Brian Hrycushko, Michael Folkert

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Radiation therapy is an integral component in the multimodality management of many gastrointestinal (GI) cancers at all stages of clinical presentation. With recent advances in technology and radiation delivery, external beam radiation therapy (EBRT) can be delivered with reduced toxicity. However, despite these advances, EBRT doses are still limited by the presence of radiosensitive serial structures near clinical targets in the GI tract. Relative to EBRT techniques, brachytherapy techniques have a lower integral dose and more rapid fall-off, allowing for high-dose delivery with little normal tissue exposure. Given the unique characteristics of brachytherapy, it is an attractive strategy to treat GI malignancies. This review addresses the application of both high-dose rate brachytherapy (HDRBT) and low-dose rate brachytherapy (LDRBT) to multiple GI malignancies for both definitive and palliative management.

Original languageEnglish (US)
Article number2
JournalCurrent Oncology Reports
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biliary brachytherapy
  • Brachytherapy
  • Endoesophageal brachytherapy
  • Endoluminal brachytherapy
  • Endorectal brachytherapy
  • Gastrointestinal malignancy
  • High-dose rate brachytherapy
  • Interstitial brachytherapy
  • Low-dose rate brachytherapy
  • Palliative care

ASJC Scopus subject areas

  • Oncology

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