Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology

Mario M. Leitao, Siobhan Kehoe, Richard R. Barakat, Kaled Alektiar, Catherine Rabbitt, Dennis S. Chi, Robert A. Soslow, Nadeem R. Abu-Rustum

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The purpose of this study was to determine posthysterectomy pathologic findings in patients with a preoperative endometrial sampling diagnosis of International Federation of Gynecology and Obstetrics (FIGO) grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia (CAH). Study Design: We reviewed 1423 consecutive cases of endometrial cancer to identify cases with a preoperative endometrial biopsy that demonstrated FIGO grade 1 endometrial adenocarcinoma. Final uterine pathologic findings were grouped into low- and high-risk based on FIGO and Gynecologic Oncology Group criteria. Results: We identified 123 cases with a background of CAH and 367 cases without a background of CAH. FIGO grade in the hysterectomy specimen was more than FIGO grade 1 in 11 of 123 cases (8.9%) with a background of CAH, compared with 60 of 359 cases (16.7%) without a background of CAH (P = .04). Conclusion: An endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of CAH is more likely to correlate with final posthysterectomy grade than a diagnosis not arising with a background of CAH.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume202
Issue number3
DOIs
StatePublished - Mar 2010

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Hysterectomy
Gynecology
Obstetrics
Hyperplasia
Adenocarcinoma
Pathology
Endometrial Neoplasms
Biopsy

Keywords

  • complex atypical hyperplasia (CAH)
  • endometrial adenocarcinoma
  • endometrial sampling
  • hysterectomy
  • posthysterectomy pathologic finding

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology. / Leitao, Mario M.; Kehoe, Siobhan; Barakat, Richard R.; Alektiar, Kaled; Rabbitt, Catherine; Chi, Dennis S.; Soslow, Robert A.; Abu-Rustum, Nadeem R.

In: American Journal of Obstetrics and Gynecology, Vol. 202, No. 3, 03.2010.

Research output: Contribution to journalArticle

Leitao, Mario M. ; Kehoe, Siobhan ; Barakat, Richard R. ; Alektiar, Kaled ; Rabbitt, Catherine ; Chi, Dennis S. ; Soslow, Robert A. ; Abu-Rustum, Nadeem R. / Endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia and final hysterectomy pathology. In: American Journal of Obstetrics and Gynecology. 2010 ; Vol. 202, No. 3.
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