Abstract
Objective: The purpose of this study was to determine posthysterectomy pathologic findings in patients with a preoperative endometrial sampling diagnosis of International Federation of Gynecology and Obstetrics (FIGO) grade 1 endometrial adenocarcinoma with a background of complex atypical hyperplasia (CAH). Study Design: We reviewed 1423 consecutive cases of endometrial cancer to identify cases with a preoperative endometrial biopsy that demonstrated FIGO grade 1 endometrial adenocarcinoma. Final uterine pathologic findings were grouped into low- and high-risk based on FIGO and Gynecologic Oncology Group criteria. Results: We identified 123 cases with a background of CAH and 367 cases without a background of CAH. FIGO grade in the hysterectomy specimen was more than FIGO grade 1 in 11 of 123 cases (8.9%) with a background of CAH, compared with 60 of 359 cases (16.7%) without a background of CAH (P = .04). Conclusion: An endometrial sampling diagnosis of FIGO grade 1 endometrial adenocarcinoma with a background of CAH is more likely to correlate with final posthysterectomy grade than a diagnosis not arising with a background of CAH.
Original language | English (US) |
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Pages (from-to) | 278.e1-278.e6 |
Journal | American journal of obstetrics and gynecology |
Volume | 202 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2010 |
Keywords
- complex atypical hyperplasia (CAH)
- endometrial adenocarcinoma
- endometrial sampling
- hysterectomy
- posthysterectomy pathologic finding
ASJC Scopus subject areas
- Obstetrics and Gynecology