Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao Wang, Antonio Zorzano, Joseph A Hill, Enrique Jaimovich, Andrew F G Quest, Sergio Lavandero

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

Original languageEnglish (US)
Pages (from-to)215-290
Number of pages76
JournalInternational Review of Cell and Molecular Biology
Volume301
DOIs
StatePublished - 2013

Fingerprint

Unfolded Protein Response
Endoplasmic Reticulum
Homeostasis
Proteins
Pathology
Medical problems
Metabolism
Organelles
Diabetes Mellitus
Cardiovascular Diseases
Calcium
Lipids
Neoplasms

Keywords

  • Calcium
  • Endoplasmic reticulum
  • ER stress
  • Metabolism
  • Organelle dynamics
  • Pathology
  • Unfolded protein response

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Cite this

Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. / Bravo, Roberto; Parra, Valentina; Gatica, Damián; Rodriguez, Andrea E.; Torrealba, Natalia; Paredes, Felipe; Wang, Zhao; Zorzano, Antonio; Hill, Joseph A; Jaimovich, Enrique; Quest, Andrew F G; Lavandero, Sergio.

In: International Review of Cell and Molecular Biology, Vol. 301, 2013, p. 215-290.

Research output: Contribution to journalArticle

Bravo, R, Parra, V, Gatica, D, Rodriguez, AE, Torrealba, N, Paredes, F, Wang, Z, Zorzano, A, Hill, JA, Jaimovich, E, Quest, AFG & Lavandero, S 2013, 'Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.', International Review of Cell and Molecular Biology, vol. 301, pp. 215-290. https://doi.org/10.1016/B978-0-12-407704-1.00005-1
Bravo, Roberto ; Parra, Valentina ; Gatica, Damián ; Rodriguez, Andrea E. ; Torrealba, Natalia ; Paredes, Felipe ; Wang, Zhao ; Zorzano, Antonio ; Hill, Joseph A ; Jaimovich, Enrique ; Quest, Andrew F G ; Lavandero, Sergio. / Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration. In: International Review of Cell and Molecular Biology. 2013 ; Vol. 301. pp. 215-290.
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