Endoplasmic Reticulum and the Unfolded Protein Response. Dynamics and Metabolic Integration.

Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao Wang, Antonio Zorzano, Joseph A Hill, Enrique Jaimovich, Andrew F G Quest, Sergio Lavandero

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221 Scopus citations

Abstract

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions essential for cellular homeostasis, development, and stress responsiveness. In response to cellular stress, a well-established signaling cascade, the unfolded protein response (UPR), is activated. This intricate mechanism is an important means of re-establishing cellular homeostasis and alleviating the inciting stress. Now, emerging evidence has demonstrated that the UPR influences cellular metabolism through diverse mechanisms, including calcium and lipid transfer, raising the prospect of involvement of these processes in the pathogenesis of disease, including neurodegeneration, cancer, diabetes mellitus and cardiovascular disease. Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies.

Original languageEnglish (US)
Pages (from-to)215-290
Number of pages76
JournalInternational Review of Cell and Molecular Biology
Volume301
DOIs
Publication statusPublished - 2013

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Keywords

  • Calcium
  • Endoplasmic reticulum
  • ER stress
  • Metabolism
  • Organelle dynamics
  • Pathology
  • Unfolded protein response

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biochemistry

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