Endoplasmic reticulum stress

Gábor Bánhegyi, Peter Baumeister, Angelo Benedetti, Dezheng Dong, Yong Fu, Amy S. Lee, Jianze Li, Changhui Mao, Éva Margittai, Min Ni, Wulf Paschen, Simona Piccirella, Silvia Senesi, Roberto Sitia, Miao Wang, Wei Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

104 Scopus citations

Abstract

Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.

Original languageEnglish (US)
Title of host publicationStress Responses
PublisherBlackwell Publishing Inc.
Pages58-71
Number of pages14
ISBN (Print)157331675X, 9781573316750
DOIs
StatePublished - Oct 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1113
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Cerebral ischemia
  • Endoplasmic reticulum
  • GRP78
  • Glucocorticoids
  • Metabolic syndrome
  • Obesity
  • Plasma cell
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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