Endoscopic management of early esophageal cancer

Jessica A. Barnes, Field F. Willingham

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The absolute incidence of esophageal adenocarcinoma has increased 7-fold over the past 5 decades, and esophageal adenocarcinoma is the most rapidly increasing epithelial malignancy in the United States. The incidence of early esophageal cancer has also increased proportionately. In the past decade, radiofrequency ablation has become the standard first-line therapy for high-grade dysplasia when found in the precursor lesion to esophageal adenocarcinoma, Barrett's esophagus. Success in the endoscopic management of high-grade dysplasia has furthered efforts to treat early esophageal cancers endoscopically. Although surgery remains the mainstay of treatment for more advanced tumors, national guidelines now recommend endoscopic mucosal resection followed by radiofrequency ablation for intramucosal carcinomas and T1a cancers. T1b cancers represent a more challenging group-very good results have been reported in highly selected subsets of patients with T1b tumors; however, many recommendations favor individualization or a surgical approach for this stage. This review examines the current data and recommendations regarding the endoscopic management of early esophageal adenocarcinomas.

Original languageEnglish (US)
Pages (from-to)638-646
Number of pages9
JournalJournal of Clinical Gastroenterology
Volume49
Issue number8
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Esophageal Neoplasms
Adenocarcinoma
Neoplasms
Barrett Esophagus
Incidence
Guidelines
Carcinoma
Therapeutics

Keywords

  • Barrett's esophagus
  • Endoscopic mucosal resection
  • Esophageal cancer
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic management of early esophageal cancer. / Barnes, Jessica A.; Willingham, Field F.

In: Journal of Clinical Gastroenterology, Vol. 49, No. 8, 01.01.2015, p. 638-646.

Research output: Contribution to journalReview article

Barnes, Jessica A. ; Willingham, Field F. / Endoscopic management of early esophageal cancer. In: Journal of Clinical Gastroenterology. 2015 ; Vol. 49, No. 8. pp. 638-646.
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